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The regenerative effect of human umbilical cord blood mesen chymal stem cells in a rabbit model of osteoarthritis
المؤلفون المشاركون
Gharbiyah, Ula M.
Afifi, Abd al-Muti
Abd al-Ghaffar, Hassan
al-Basyuni, Sharif
al-Sayyid, Azizah
Mahmud, Amil A.
Yusuf, Amir
Lutfi, Ahmad
al-Hawwari, Amirah Kamal
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 42، العدد 4 (31 ديسمبر/كانون الأول 2015)، ص ص. 163-169، 7ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2015-12-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background Osteoarthritis (OA) is a degenerative disorder characterized by changes in subchondral and periarticular bone.
The limited number of therapeutic choices for articular injury and disease has increased the need for stem cells as a biological replacement for damaged cartilage.
Umbilical cord (UC) blood cells are easily available and less immunogenic than other sources of stem cells, and there are no ethical concerns surrounding their use.
These cells are isolated from young donors.
Human umbilical cord blood mesenchymal stem cells (HUCB-MSCs) appear to be an ideal candidate for cartilage regeneration.
Objective The aim of the study was to investigate the regenerative effect of HUCB stem cells on degenerated articular cartilage in New Zealand white rabbits experimentally induced with OA.
Materials and methods This study was performed on 42 New Zealand white rabbits.
They were surgically induced with OA in the left knees by cutting the anterior cruciate ligament.
After confirmation of the development of OA histopathologically, we delivered a single dose of HUCB-MSCs directly intra-articularly in the cell-treated groups.
Controls were injected with only suspension media.
Histopathological tests were performed 8 and 24 weeks after injection.
Results Histopathologically, 8 weeks after the injection, cell-treated rabbits showed better cartilage quality and lower degree of degeneration, whereas 24 weeks after the injection all parameters in the cell-treated groups were significantly better.
Conclusion HUCB-MSCs are a promising stem cell source for cartilage tissue formation and can decrease the development of OA in rabbits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Ghaffar, Hassan& al-Basyuni, Sharif& al-Hawwari, Amirah Kamal& Lutfi, Ahmad& al-Sayyid, Azizah& Mahmud, Amil A.…[et al.]. 2015. The regenerative effect of human umbilical cord blood mesen chymal stem cells in a rabbit model of osteoarthritis. Egyptian Rheumatology and Rehabilitation،Vol. 42, no. 4, pp.163-169.
https://search.emarefa.net/detail/BIM-629072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Ghaffar, Hassan…[et al.]. The regenerative effect of human umbilical cord blood mesen chymal stem cells in a rabbit model of osteoarthritis. Egyptian Rheumatology and Rehabilitation Vol. 42, no. 4 (Dec. 2015), pp.163-169.
https://search.emarefa.net/detail/BIM-629072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Ghaffar, Hassan& al-Basyuni, Sharif& al-Hawwari, Amirah Kamal& Lutfi, Ahmad& al-Sayyid, Azizah& Mahmud, Amil A.…[et al.]. The regenerative effect of human umbilical cord blood mesen chymal stem cells in a rabbit model of osteoarthritis. Egyptian Rheumatology and Rehabilitation. 2015. Vol. 42, no. 4, pp.163-169.
https://search.emarefa.net/detail/BIM-629072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 168-169
رقم السجل
BIM-629072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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