Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity : a clinical and ultrasound study
المؤلفون المشاركون
Labib, Ala A.
Salah, Daliyah
al-Hewala, Abd al-Samad Ibrahim
Sulayman, Samar G.
Musa, Walid A.
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 42، العدد 4 (31 ديسمبر/كانون الأول 2015)، ص ص. 178-182، 5ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2015-12-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective The aim of this study was to measure the level of interleukin-17A (IL-17A) in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and its relation to disease activity.
Patients and methods A total of 100 patients suffering from RA were chosen from the outpatient clinic, Department of Physical Medicine and Rehabilitation, Menoufia University Hospital.
The patient group was divided into three subgroups-mild, moderate, and severe-according to the disease activity score.
All patients were subjected to clinical, laboratory, and ultrasound evaluation and to measurement of IL-17A in the serum and synovial fluid by means of the enzyme-linked immunosorbent assay technique.
Fifty healthy individuals were evaluated for IL-17A level in the blood, and served as the control group.
Results The present study revealed an increase in serum (P = 3.1) and synovial fluid (P = 5.2) IL-17A levels in RA patients with increased disease activity.
The ultrasound study showed an increase in serum IL-17A levels with increased erosion of the knee (P = 5.99) and wrist (P = 5.03).
There was an increase in serum IL-17A with increased effusion of the knee (P = 22.6) and wrist (P = 33.3).
There was an increase in serum IL-17A with increased synovial hypertrophy of the knee (P = 6.39), wrist (P = 12.23), and second metacarpophalangeal (MCP) (P = 53.34).
Finally, there was an increase in the blood IL-17A level, dryness of the eye (P = 3.8), dryness of the mouth (P = 3.2), and number of subcutaneous nodules (P = 2.5).
Conclusion In our study; the mean serum and synovial IL-17A levels were found in high titers in patients with disease activity, and with extra-articular manifestations like dry eyes, dry mouth, and subcutaneous nodules.
Also erosions, synovial hypertrophy, and effusions were found with significantly high titers of IL-17A, denoting its usefulness as a measurement tool for high disease activity and destruction.
Also targeting IL-17A may be useful as a treatment option for aggressive disease and for rheumatoid patients with poor prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hewala, Abd al-Samad Ibrahim& Sulayman, Samar G.& Labib, Ala A.& Musa, Walid A.& Salah, Daliyah. 2015. Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity : a clinical and ultrasound study. Egyptian Rheumatology and Rehabilitation،Vol. 42, no. 4, pp.178-182.
https://search.emarefa.net/detail/BIM-629096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sulayman, Samar G.…[et al.]. Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity : a clinical and ultrasound study. Egyptian Rheumatology and Rehabilitation Vol. 42, no. 4 (Dec. 2015), pp.178-182.
https://search.emarefa.net/detail/BIM-629096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hewala, Abd al-Samad Ibrahim& Sulayman, Samar G.& Labib, Ala A.& Musa, Walid A.& Salah, Daliyah. Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity : a clinical and ultrasound study. Egyptian Rheumatology and Rehabilitation. 2015. Vol. 42, no. 4, pp.178-182.
https://search.emarefa.net/detail/BIM-629096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 181-182
رقم السجل
BIM-629096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر