Evaluating the role of corticosteroid pulse therapy in patients with secondary progressive multiple sclerosis receiving mitoxantrone : a double blind randomized controlled clinical trial
المؤلفون المشاركون
Rahimdil, Abu al-Qasim
Zaynali, Ahmad
Mellat, Ali
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 17، العدد 10 (31 أكتوبر/تشرين الأول 2015)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2015-10-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Multiple sclerosis (MS) is a central nervous system disorder with periods of recurrence and recovery.
Mitoxantrone has been approved for secondary progressive MS (SPMS) treatment but data lacks the role of corticosteroid pulse therapy in SPMS.
Objectives: To evaluate the role of corticosteroid pulse therapy in patients with SPMS receiving mitoxantrone.
Patients and Methods: A double blind randomized controlled clinical trial was performed on 71 patients with SPMS referred to Shahid Sadoughi Hospital (Yazd, Iran) for receiving mitoxantrone in two groups.
The first group (35 patients) received 20 mg mitoxantrone plus 500 mg methylprednisolone monthly for six months.
The second group (36 patients) received the same dosage of mitoxantrone plus 100 CC of 5% dextrose water monthly for six months.
Expanded disability status scale (EDSS), MRI plaques in both groups before and after the treatment completion and six months after the end of trial were compared together.
Results: 28 men and 43 women enrolled in the study.
MRI plaques number reduced in groups significantly (2.29 vs.
2.17) without significant difference between the groups (P = 0.782).
Six months after trial completion, plaques number increased in groups without significantly difference (0.72 vs.
0.77, P = 0.611).
The mean value of EDSS showed significant reduction at the end of treatment in groups (0.79 and 0.53) without significant difference between the groups (P = 0.953).
Six months after trial completion, EDSS increased in groups without significant difference (0.35 vs.
0.43, P = 0.624).
Conclusions: Corticosteroid pulse therapy in SPMS was effective in inflammatory process, but could not postpone or decline the neurodegenerative process and besides the imposing side effects could not result in significant improvement in EDSS and MRI plaques number in long term.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahimdil, Abu al-Qasim& Zaynali, Ahmad& Mellat, Ali. 2015. Evaluating the role of corticosteroid pulse therapy in patients with secondary progressive multiple sclerosis receiving mitoxantrone : a double blind randomized controlled clinical trial. Iranian Red Crescent Medical Journal،Vol. 17, no. 10, pp.1-6.
https://search.emarefa.net/detail/BIM-629137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahimdil, Abu al-Qasim…[et al.]. Evaluating the role of corticosteroid pulse therapy in patients with secondary progressive multiple sclerosis receiving mitoxantrone : a double blind randomized controlled clinical trial. Iranian Red Crescent Medical Journal Vol. 17, no. 10 (Oct. 2015), pp.1-6.
https://search.emarefa.net/detail/BIM-629137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahimdil, Abu al-Qasim& Zaynali, Ahmad& Mellat, Ali. Evaluating the role of corticosteroid pulse therapy in patients with secondary progressive multiple sclerosis receiving mitoxantrone : a double blind randomized controlled clinical trial. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 10, pp.1-6.
https://search.emarefa.net/detail/BIM-629137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-6
رقم السجل
BIM-629137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر