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immune-histological assessment of sub-clinical acute and borderline rejection in renal allograft recipients : data from a transplant center in India
المؤلفون المشاركون
Badwal, Sonia
Huda, A. K.
Varma, P. P.
Kumar, Arun
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 26، العدد 6 (31 ديسمبر/كانون الأول 2015)، ص ص. 1232-1240، 9ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
This single-center study was carried out on living related and unrelated renal transplant recipients (RTRs) to evaluate the usefulness of surveillance biopsies in monitoring stable renal allografts using immuno-histological markers for immune-activation.
This is a prospective, longitudinal study.
Protocol biopsies of 60 RTRs with stable graft function were evaluated at three, six and 12 months post-transplant.
Immuno-histological evaluation was carried out using immune-activation markers (perforins, granzyme and interleukin-2R), phenotypic markers (CD-3 and CD-20), viral markers and C4d.
The demographic and clinical profile was recorded for each patient.
All cases of acute sub-clinical rejection (SCR) were treated and borderline SCR cases were followed-up without treatment.
SCR at three and six months post-transplant was evident in 16.7 % and 3.7 % of RTRs, respectively.
Positive statistical association of SCR was seen with HLA-DR mismatches, whereas patients receiving induction therapy and tacrolimus-based immunosuppression exhibited a lower incidence of SCR.
T cell phenotype with persistent expression of immune-activation markers exhibited positive statistical association with interstitial fibrosis and tubular atrophy at 12-month follow-up biopsy.
The mean creatinine levels were significantly lower in the protocol biopsy group than the non-protocol biopsy group.
No significant difference was found between the mean creatinine levels of the SCR group after treatment and the non-SCR cases within the protocol biopsy group.
Early treatment of sub-clinical acute rejection leads to better functional outcomes.
However, persistent immune-activation is associated with chronicity and may have implications on long-term graft survival.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Badwal, Sonia& Kumar, Arun& Huda, A. K.& Varma, P. P.. 2015. immune-histological assessment of sub-clinical acute and borderline rejection in renal allograft recipients : data from a transplant center in India. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 6, pp.1232-1240.
https://search.emarefa.net/detail/BIM-629544
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Badwal, Sonia…[et al.]. immune-histological assessment of sub-clinical acute and borderline rejection in renal allograft recipients : data from a transplant center in India. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 6 (Nov. / Dec. 2015), pp.1232-1240.
https://search.emarefa.net/detail/BIM-629544
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Badwal, Sonia& Kumar, Arun& Huda, A. K.& Varma, P. P.. immune-histological assessment of sub-clinical acute and borderline rejection in renal allograft recipients : data from a transplant center in India. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 6, pp.1232-1240.
https://search.emarefa.net/detail/BIM-629544
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1239-1240
رقم السجل
BIM-629544
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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