Risk factors of graft survival after diagnosis of post-kidney transplant malignancy : using Cox proportional hazard model
المؤلفون المشاركون
Mehrazmay, Ali Rida
Muhammadi, Jamile
Eshraghian, Muhammad Rida
Salesi, Mahmud
Foroushani, Abbas Rahimi
Rostami, Zahrah
Einollahi, Behzad
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 17، العدد 11 (30 نوفمبر/تشرين الثاني 2015)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2015-11-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: All recipients of kidney transplantation, especially those with posttransplant malignancy, are at risk of long-term graft failure.
Objectives: The purpose of our study was to evaluate the risk factors associated with graft survival after diagnosis of malignancy.
Patients and Methods: To reach this purpose, we conducted a historical cohort study in Iran and 266 cases with posttransplant malignancy were followed up from diagnosis of malignancy until long-term graft loss or the date of last visit.
These patients were taken as a census from 16 Transplant Centers in Iran during 22 years follow-up period since October 1984 to December 2008.
A Cox proportional hazards model was performed to determine the important independent predictors of graft survival after malignancy.
Results: At the end of the study, long-term graft failure was seen in 27 (10.2%) cases.
One-year and 2-year graft survival after diagnosis of cancer were 93.6% and 91.7%, respectively.
The univariate analysis showed that the incidence of chronic graft loss was significantly higher in male patients with solid cancers, withdrawal of immunosuppressant regimen, no response to treatment, and tumor metastasis.
In continuation, the Cox model indicated that the significant risk factors associated with graft survival were type of cancer (P < 0.0001), response to treatment (P < 0.0001, HR = 0.14, 95% CI: 0.06 - 0.32), metastasis (P < 0.0001, HR = 5.68, 95% CI: 2.24 - 14.42), and treatment modality (P = 0.0001).
Conclusions: By controlling the modifiable risk factors and modality of treatment in our study, physicians can reach more effective treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Foroushani, Abbas Rahimi& Rostami, Zahrah& Mehrazmay, Ali Rida& Muhammadi, Jamile& Einollahi, Behzad& Eshraghian, Muhammad Rida…[et al.]. 2015. Risk factors of graft survival after diagnosis of post-kidney transplant malignancy : using Cox proportional hazard model. Iranian Red Crescent Medical Journal،Vol. 17, no. 11, pp.1-6.
https://search.emarefa.net/detail/BIM-632826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Foroushani, Abbas Rahimi…[et al.]. Risk factors of graft survival after diagnosis of post-kidney transplant malignancy : using Cox proportional hazard model. Iranian Red Crescent Medical Journal Vol. 17, no. 11 (Nov. 2015), pp.1-6.
https://search.emarefa.net/detail/BIM-632826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Foroushani, Abbas Rahimi& Rostami, Zahrah& Mehrazmay, Ali Rida& Muhammadi, Jamile& Einollahi, Behzad& Eshraghian, Muhammad Rida…[et al.]. Risk factors of graft survival after diagnosis of post-kidney transplant malignancy : using Cox proportional hazard model. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 11, pp.1-6.
https://search.emarefa.net/detail/BIM-632826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-6
رقم السجل
BIM-632826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر