Comparative study of the effects of melatonin and vitamin E on serum insulin level and lipid profile in normal and diabetic rats
المؤلفون المشاركون
Mahmud, Ala H.
al-Muhandis, Amr S.
Muhanna, Radawi
Shararah, Jihan M.
المصدر
Journal of the Medical Research Institute
العدد
المجلد 26، العدد 1 (31 مارس/آذار 2005)، ص ص. 24-29، 6ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2005-03-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Diabetes mellitus markedly raises the risk of micro vascular and macro vascular diseases.
There is a clearly documented link between diabetic complications and lipid peroxidation.
The present study aimed at studying the antioxidant effects of both melatonin and vitamin E on serum insulin level and lipid profile in normal and diabetic rats.
This study was carried out on 60 albino rats divided into 2 main groups control and diabetics each of them is further subdivided into 3 subgroups.
(n=10).
The results of this study revealed that both vitamin E and melatonin in normal rats produced significant increase in insulin and tissue glutathione peroxidase levels and significant decrease in malondialdehyde (MDA) level, but both produced insignificant effects on lipid profile.
In diabetic rats melatonin produced significant decrease in cholesterol, triglycerides, LDL cholesterol and free fatty acid (F.F.A) levels in addition; there was significant increase in HDL cholesterol.
Vitamin E had the same melatonin effect, but to a lesser extent. Similarly, the antioxidant effect of melatonin in diabetic rats resulted in more suppression of tissue MDA level compared to effect of vitamin E.
Also, tissue glutathione peroxidase activity was significantly higher in melatonin treated diabetic rats compared to vitamin E treated diabetic rats.
From this study we can conclude that the antioxidant effect of melatonin is more potent than that of vitamin E, so, it can be used in preventing diabetic complications and correcting dyslipidemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmud, Ala H.& al-Muhandis, Amr S.& Shararah, Jihan M.& Muhanna, Radawi. 2005. Comparative study of the effects of melatonin and vitamin E on serum insulin level and lipid profile in normal and diabetic rats. Journal of the Medical Research Institute،Vol. 26, no. 1, pp.24-29.
https://search.emarefa.net/detail/BIM-63411
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmud, Ala H.…[et al.]. Comparative study of the effects of melatonin and vitamin E on serum insulin level and lipid profile in normal and diabetic rats. Journal of the Medical Research Institute Vol. 26, no. 1 (2005), pp.24-29.
https://search.emarefa.net/detail/BIM-63411
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmud, Ala H.& al-Muhandis, Amr S.& Shararah, Jihan M.& Muhanna, Radawi. Comparative study of the effects of melatonin and vitamin E on serum insulin level and lipid profile in normal and diabetic rats. Journal of the Medical Research Institute. 2005. Vol. 26, no. 1, pp.24-29.
https://search.emarefa.net/detail/BIM-63411
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 27-29
رقم السجل
BIM-63411
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر