Spectrophotometric determination of procainamide hydrochloride by p-benzoquinone

الملخص EN

The method described here is based on the reaction of Procainamide hydrochloride with p-benzoquinone in the presence of sodium dehydrogenase orthophosphate at 90˚C to form a brown product which shows maximum absorbance at 501nm.

Linear calibration graph from 1-75 µg / ml of Procainamide hydrochloride was obtained by measuring the absorbance of the brown product at 501nm.

Less than 0.5µg / ml of Procainamide hydrochloride can be detected.

The method was applied to the determination of procainamide hydrochloride in priestly tablets and gave good results.

The relative standard deviation.

Ten determinations was 1.03 %