The photostability study of gatifloxacin under stressed conditions
المؤلفون المشاركون
al-Bari, Ahmad A.
Sulayman, Iman I.
Ali, Maha Fadil M.
Abd al-Wahid, Tariq Y.
al-Menshawee, Shahira F.
المصدر
Journal of the Medical Research Institute
العدد
المجلد 26، العدد 2 (30 يونيو/حزيران 2005)، ص ص. 128-136، 9ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2005-06-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
-The photo stability of gatifloxacin, (an 8-methoxy fluoroquinolone antibacterial agent), as a raw material in both solution form as well as in tablet formulations was studied applying the International Conference on Harmonization (ICH) conditions.
In addition, the effect of packaging of this dosage form on the photo stability of the drug was determined.
The light irradiation was performed using a solar simulator of Xenon lamp within a wavelength range 250-400 nm.
Samples were irradiated with two light doses for a period of 90 minutes.
Dose I was 3 W/m2 / h visible light, 50 W/m2 /h UVA, and 2.9 W/m2 /h UVB; and Dose II was 6.5 W/m2/h visible light, and 150 W/m2 /h UVA, and 12.38 W/m2 /h UVB.
The photo degradation process was monitored by UV spectrophotometry and Fourier transformer Infra-Red.
All of the prepared tablets unpackaged and in blister, together with the commercially available Sequin (Bristol-Myers Squibb) tablets in blister sheet (marketing pack), and gatifloxacin in solution showed neither discoloration nor change in appearance when exposed to the used dose I of light.
On the contrary, exposing gatifloxacin powder to the dose II of light caused color change.
A negligible degradation of gatifloxacin was noted for the drug in raw material (powder) irradiated with Dose II where 97.94% gatifloxacin remaining, while gatifloxacin solution (salt) was relatively more affected with 92.7 % gatifloxacin remaining after 90 minutes exposure to dose II.
The percentage of gatifloxacin remaining after 90 minutes exposure of unpackaged tablets to dose I and dose II were acceptable where 99.1 and 98.34 % drug remaining respectively.
However, there was 2.65 % degradation of gatifloxacin in sequin tablets in blister packaging after 90 minutes exposure to dose II of light, while the prepared tablet showed no degradation after 90 minutes exposure to the same dose.
Finally, it could be concluded that the prepared tablets were photos table on stressed conditions and it was dependent on excipients used in the formulation of tablets and the presence of packaging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Bari, Ahmad A.& Sulayman, Iman I.& Ali, Maha Fadil M.& Abd al-Wahid, Tariq Y.& al-Menshawee, Shahira F.. 2005. The photostability study of gatifloxacin under stressed conditions. Journal of the Medical Research Institute،Vol. 26, no. 2, pp.128-136.
https://search.emarefa.net/detail/BIM-64001
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Bari, Ahmad A.…[et al.]. The photostability study of gatifloxacin under stressed conditions. Journal of the Medical Research Institute Vol. 26, no. 2 (2005), pp.128-136.
https://search.emarefa.net/detail/BIM-64001
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Bari, Ahmad A.& Sulayman, Iman I.& Ali, Maha Fadil M.& Abd al-Wahid, Tariq Y.& al-Menshawee, Shahira F.. The photostability study of gatifloxacin under stressed conditions. Journal of the Medical Research Institute. 2005. Vol. 26, no. 2, pp.128-136.
https://search.emarefa.net/detail/BIM-64001
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p.136
رقم السجل
BIM-64001
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر