Prevalence and correlation of human papilloma virus and its types with prognostic markers in patients with invasive ductal carcinoma of the breast in Kuwait
العناوين الأخرى
انتشار وعلاقة فيروس الورم البشري الحليمي وأنواعه بمؤشرات الورم المعروفة بين مرضى أورام الثدي في الكويت
المؤلفون المشاركون
Faranisi, Isam
al-Ayyadi, Bushra
al-Awadi, Shafiqah A. A.
al-Mulla, Fahd
Kapila, Kusum
المصدر
Sultan Qaboos University Medical Journal
العدد
المجلد 13، العدد 4 (30 نوفمبر/تشرين الثاني 2013)، ص ص. 527-533، 7ص.
الناشر
جامعة السلطان قابوس كلية الطب و العلوم الصحية
تاريخ النشر
2013-11-30
دولة النشر
سلطنة عمان
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study aimed to document the association of human papilloma virus (HPV) and its types in breast carcinoma tissues in Kuwaiti women, and correlate this with known prognostic markers.
Methods: The clinicopathological data of archived tissue from 144 cases of invasive ductal breast carcinoma were studied (age, histological grade, size of tumour, lymph node metastases, oestrogen/progesterone receptors and human epidermal growth factor receptor 2 status).
HPV frequency was documented using immunohistochemistry (IHC) and chromogenic in-situ hybridisation (CISH).
HPV types were documented by CISH using HPV probes.
CISH and IHC techniques were compared and HPV correlated with prognostic parameters.
Results: The HPV prevalence as determined by CISH and IHC was 51 (35.4%) and 24 (16.7%) cases, respectively.
The sensitivity of HPV by IHC was 37.3% and specificity was 94.6%.
The sensitivity and specificity of HPV-CISH compared to HPVIHC was statistically significant (P <0.001).
HPV-CISH was seen in 51 cases.
A combination of HPV 6 and 11, and 16 and 18 was seen in 2 (3.9%) cases, and a combination of HPV 6, 11, 31 and 33 was seen in 7 (13.7%) cases.
All three HPV probes: 6 and 11, 16 and 18, as well as 31 and 33 were present in 2 (3.9%) cases.
The prevalence of HPVCISH in the Kuwaiti and non-Kuwaiti populations was 27 (52.9%) and 19 (37.2%), respectively.
No correlation was observed with the prognostic parameters.
Conclusion: The frequency of HPV in breast carcinoma cases in Kuwait was 35.4% (CISH).
Of those, 52.9% were Kuwaitis in whom both low- and high-risk HPV types were detected.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Faranisi, Isam& al-Ayyadi, Bushra& al-Awadi, Shafiqah A. A.& Kapila, Kusum& al-Mulla, Fahd. 2013. Prevalence and correlation of human papilloma virus and its types with prognostic markers in patients with invasive ductal carcinoma of the breast in Kuwait. Sultan Qaboos University Medical Journal،Vol. 13, no. 4, pp.527-533.
https://search.emarefa.net/detail/BIM-642405
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Ayyadi, Bushra…[et al.]. Prevalence and correlation of human papilloma virus and its types with prognostic markers in patients with invasive ductal carcinoma of the breast in Kuwait. Sultan Qaboos University Medical Journal Vol. 13, no. 4 (Nov. 2013), pp.527-533.
https://search.emarefa.net/detail/BIM-642405
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Faranisi, Isam& al-Ayyadi, Bushra& al-Awadi, Shafiqah A. A.& Kapila, Kusum& al-Mulla, Fahd. Prevalence and correlation of human papilloma virus and its types with prognostic markers in patients with invasive ductal carcinoma of the breast in Kuwait. Sultan Qaboos University Medical Journal. 2013. Vol. 13, no. 4, pp.527-533.
https://search.emarefa.net/detail/BIM-642405
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 532-533
رقم السجل
BIM-642405
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر