Role of interleukin-8 and interleukin-10 in rheumatoid arthritis patients : correlation with disease Activity
المؤلفون المشاركون
Abu Shushah, Siham A.
Husayn, Muhammad Z.
al-Zawawi, Ashraf I.
المصدر
Journal of the Medical Research Institute
العدد
المجلد 26، العدد 3 (30 سبتمبر/أيلول 2005)7ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2005-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background The synovial membrane of rheumatoid arthritis (RA) is characterized by infiltrate of a variety of inflammatory cells, such as lymphocytes, macrophages and dendritic cells, together with proliferation of synovial fibroblast-like cells.
Numerous pro-inflammatory and anti-inflammatory cytokines are overproduced in the inflamed joint by these cells.
Aim this study aimed to investigate the possible role of IL-8 and IL-10 as representatives of the pro-and anti-inflammatory cytokines in the pathogenesis of RA in correlation with the disease activity.
The level of IL-8 and IL-10 were measured by ELISA technique in LPS-stimulated and non-stimulated PBMCs of active and inactive RA groups and the results were compared with a group of healthy normal sex and age matched subjects as controls. Results: revealed that IL-8 and IL-10 levels in LPS stimulated and non-stimulated PBMCS of both RA groups of patients were higher than the normal subjects.
The level of IL-8 is significantly elevated in both LPS-stimulated and non-stimulate PBMCs in active RA than inactive RA.
Insignificant elevation of IL-10 in non-stimulated PBMCs of active RA than inactive RA is observed while its level is insignificantly decreased in LPS-stimulated PBMCs in active RA than inactive RA. Conclusion we suggested that the chemokine / prionflammatory cytokine IL-8 and suppressor/anti-inflammatory cytokine IL-10 released by PBMCs of RA positively correlated with the activity of the disease and that the modulation of their production to keep the balance between pro- and anti-inflammatory cytokines may be a new mode of treatment of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abu Shushah, Siham A.& al-Zawawi, Ashraf I.& Husayn, Muhammad Z.. 2005. Role of interleukin-8 and interleukin-10 in rheumatoid arthritis patients : correlation with disease Activity. Journal of the Medical Research Institute،Vol. 26, no. 3.
https://search.emarefa.net/detail/BIM-64362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abu Shushah, Siham A.…[et al.]. Role of interleukin-8 and interleukin-10 in rheumatoid arthritis patients : correlation with disease Activity. Journal of the Medical Research Institute Vol. 26, no. 3 (2005).
https://search.emarefa.net/detail/BIM-64362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abu Shushah, Siham A.& al-Zawawi, Ashraf I.& Husayn, Muhammad Z.. Role of interleukin-8 and interleukin-10 in rheumatoid arthritis patients : correlation with disease Activity. Journal of the Medical Research Institute. 2005. Vol. 26, no. 3.
https://search.emarefa.net/detail/BIM-64362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-64362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر