Sequential chemo radiotherapy for locally advanced laryngeal and hypo pharyngeal cancer
العناوين الأخرى
العلاج الكيميائي-الإشعاعي المتتابع في حلات سرطان الحنجرة و البلعوم المتقدمة موضعيا
المؤلفون المشاركون
Muhammad, Ayat Mursi
Mustafa, Hanan Jamal al-Din
Makkawi, Muhammad Abd al-Hakim
Abd al-Halim, Ala Kamil
Ali, Samiyah Abd al-Karim
المصدر
العدد
المجلد 39، العدد 1 (31 يناير/كانون الثاني 2015)، ص ص. 1-14، 14ص.
الناشر
تاريخ النشر
2015-01-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Purpose: This prospective phase 11 study presents our experience with induction chemotherapy (IC) followed by concurrent chemoradiotherapy regimen in our department.
patients and methods: patients diagnosed with locally advanced squamus cell carcinoma (SCC) of the larynx and hypo pharynx who were attended from February 2010 to Aprl120l4 underwent 3 cycles of 1C at a dose of75mg/m2 docetaxel Dl, 100mg/m2 cisplatin Dl, 1000mg/m2 5-fluorouraci! D 1-4 every 3 weeks for 3 cycles followed by concurrent radiotherapy and weekly cisplatin 30mg/m2.
Results: Thirty-three patients were enrolled in the study and thirty patients completed the treatment.
The median duration of follow-up was 18 months.
The median age at diagnosis was 51 years and stage !٧ was 73%.
After sequential therapy, a complete response and partial response was seen in 9 (30%) and 12 (40%) patients respectively.
The overall response rate was 70%.
Median survival was 17 months and median progression-free survival (PFS) was 8months.
Grade 3-4 toxicity of TFF was as follow: grade 3-4 neutropenia and anemia occurred in 40% and 10% respectively.
Three patients died during 10 due to hematclogic toxicity.
Prognostic factors for response and PFS were females, non-smokers, T3& N0-1 stage and laryngeal site.
Concision: TPF induction chemotherapy followed by concurrent chemoradiotherpy showed a high response rate and long Progression-free survival in Egyptian patients with locally advanced laryngeal and hypopharyngeal cancer.
significant better response and longer progression-free survival were achieved in stage 111 laryngeal carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Makkawi, Muhammad Abd al-Hakim& Ali, Samiyah Abd al-Karim& Abd al-Halim, Ala Kamil& Mustafa, Hanan Jamal al-Din& Muhammad, Ayat Mursi. 2015. Sequential chemo radiotherapy for locally advanced laryngeal and hypo pharyngeal cancer. Assiut Medical Journal،Vol. 39, no. 1, pp.1-14.
https://search.emarefa.net/detail/BIM-646011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Makkawi, Muhammad Abd al-Hakim…[et al.]. Sequential chemo radiotherapy for locally advanced laryngeal and hypo pharyngeal cancer. Assiut Medical Journal Vol. 39, no. 1 (Jan. 2015), pp.1-14.
https://search.emarefa.net/detail/BIM-646011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Makkawi, Muhammad Abd al-Hakim& Ali, Samiyah Abd al-Karim& Abd al-Halim, Ala Kamil& Mustafa, Hanan Jamal al-Din& Muhammad, Ayat Mursi. Sequential chemo radiotherapy for locally advanced laryngeal and hypo pharyngeal cancer. Assiut Medical Journal. 2015. Vol. 39, no. 1, pp.1-14.
https://search.emarefa.net/detail/BIM-646011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 12-13
رقم السجل
BIM-646011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر