Relationship of obesity with serum concentrations of leptin, CRP and IL-6 in breast cancer survivors
المؤلفون المشاركون
Babai, Zaynab
Muslim, Darwish
Parsian, Hadi
Pouramir, Mahdi
Mosapour, Abbas
Khafri, Thuryah
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 27، العدد 4 (31 ديسمبر/كانون الأول 2015)، ص ص. 223-229، 7ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2015-12-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Introduction: Several mechanisms have been proposed to explain the adverse effect of obesity on quality of life among women with breast cancer, including alteration in some inflammatory markers.
The aim of this study was to determine the status of serum levels of leptin, IL-6 and CRP in obese, overweight and normal weight breast cancer survivors in order to determine the relationship between inflammatory markers’ levels and obesity.
Materials and methods: This cross-sectional study was done on 75 women with breast cancer, 30 obese, 15 overweight and 30 normal weight patients.
Serum leptin, IL-6, CRP, total protein, albumin and lipid profile as well as anthropometric parameters were measured in three groups.
Results: Serum leptin levels of obese patients were significantly higher than those of overweight and normal weight patients (P <0.05).
Higher serum CRP and lower albumin levels were observed in obese patients in comparison with normal weight patients (P <0.05).
HDL-C level was significantly different between overweight and normal weight patients (P < 0.05).
Significant differences in serum IL-6 levels were not observed between the study groups (P > 0.05).
Moreover, multiple regression analysis showed that leptin was significantly associated with BMI (P < 0.001), while albumin was negatively correlated with BMI (P < 0.05).
CRP levels were significantly correlated with BMI and waist-to-hip ratio (WHR) (P < 0.05).
Conclusions: In conclusion, high leptin levels and alteration in acute phase proteins in obese patients may exaggerate the inflammation status.
As inflammation has the potential to increase the susceptibility of the patients to metastasis development, it is necessary to decline its rate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Babai, Zaynab& Muslim, Darwish& Parsian, Hadi& Khafri, Thuryah& Pouramir, Mahdi& Mosapour, Abbas. 2015. Relationship of obesity with serum concentrations of leptin, CRP and IL-6 in breast cancer survivors. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 4, pp.223-229.
https://search.emarefa.net/detail/BIM-648760
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Babai, Zaynab…[et al.]. Relationship of obesity with serum concentrations of leptin, CRP and IL-6 in breast cancer survivors. Journal of the Egyptian National Cancer Institute Vol. 27, no. 4 (Dec. 2015), pp.223-229.
https://search.emarefa.net/detail/BIM-648760
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Babai, Zaynab& Muslim, Darwish& Parsian, Hadi& Khafri, Thuryah& Pouramir, Mahdi& Mosapour, Abbas. Relationship of obesity with serum concentrations of leptin, CRP and IL-6 in breast cancer survivors. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 4, pp.223-229.
https://search.emarefa.net/detail/BIM-648760
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 228-229
رقم السجل
BIM-648760
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر