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A comparative study of prophylactic intravenous granisetron, ondansetron, and ephedrine in attenuating hypotension and its effect on motor and sensory block in elective cesarean section under spinal anesthesia
المؤلف
المصدر
Ain Shams Journal of Anesthesiology
العدد
المجلد 8، العدد 2 (30 يونيو/حزيران 2015)، ص ص. 166-172، 7ص.
الناشر
جامعة عين شمس كلية الطب قسم التخدير
تاريخ النشر
2015-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Context Although spinal anesthesia avoids the risks involved in managing the airway of the parturient, an undesired side effect often seen is hypotension.
Prophylactic intravenous (i.v.) administration of vasopressors such as ephedrine or of serotonin receptor antagonists such as granisetron and ondansetron has been used to overcome this problem.
Aims The aim of the study was to compare granisetron and ondansetron with the traditionally used vasopressor ‘ephedrine’ in reducing hypotension following spinal anesthesia and their effect on sensory and motor blockade in parturients undergoing cesarean section.
Settings and design This study was designed as a randomized, prospective, double-blind, placebo-controlled trial.
Materials and methods Eighty parturients of ASA I or II grade, aged 2040 years, scheduled for elective cesarean section were randomly allocated into four equal groups (G, O, E, and C).
‘Group G’ received 1 mg i.v.
granisetron, ‘group O’ received 4 mg i.v.
ondansetron, ‘group E’ received 10 mg i.v.
ephedrine, and ‘group C’ received 10 ml normal saline.
All of the studied drugs were diluted in 10 ml normal saline and administered over a period of 1–5 min before induction of spinal anesthesia.
Mean arterial blood pressure, heart rate, sensory and motor blockade, nausea, shivering, bradycardia and vasopressor need were assessed.
Results The reduction in mean arterial pressure was signifi cantly lower in the therapeutic groups, with the best results recorded in the O group and nearly comparable results in G and E groups.
Heart rate was statistically different only at 10 and 15 min.
No signifi cant difference was seen in motor block or in the incidence of bradycardia.
Signifi cantly faster recovery of sensation was detected in the G group.
Groups G, O, and E had signifi cantly less vasopressor need and lower incidence of nausea.
Conclusion In the cesarean section, prophylactic use of i.v.
granisetron, ondansetron, or ephedrine reduced the severity of spinal-induced hypotension, nausea, and vasopressor need, but faster recovery of sensory block was noticed with granisetron.-
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khalifah, Umaymah Sh. M.. 2015. A comparative study of prophylactic intravenous granisetron, ondansetron, and ephedrine in attenuating hypotension and its effect on motor and sensory block in elective cesarean section under spinal anesthesia. Ain Shams Journal of Anesthesiology،Vol. 8, no. 2, pp.166-172.
https://search.emarefa.net/detail/BIM-650036
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalifah, Umaymah Sh. M.. A comparative study of prophylactic intravenous granisetron, ondansetron, and ephedrine in attenuating hypotension and its effect on motor and sensory block in elective cesarean section under spinal anesthesia. Ain Shams Journal of Anesthesiology Vol. 8, no. 2 (Apr. / Jun. 2015), pp.166-172.
https://search.emarefa.net/detail/BIM-650036
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khalifah, Umaymah Sh. M.. A comparative study of prophylactic intravenous granisetron, ondansetron, and ephedrine in attenuating hypotension and its effect on motor and sensory block in elective cesarean section under spinal anesthesia. Ain Shams Journal of Anesthesiology. 2015. Vol. 8, no. 2, pp.166-172.
https://search.emarefa.net/detail/BIM-650036
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 171-172
رقم السجل
BIM-650036
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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