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Synthesis, Identification and evaluation of antibacterial activity of some new substituted N-benzyl-5-Bromo Isatin
العناوين الأخرى
تحضير، تشخيص و تقييم الفعالية المضادة للبكتريا لعدد من المعوضات الجديدة ل N-بن ا زيل 5 بروموايساتين
المؤلفون المشاركون
al-Adhami, Huda Jamal Ahmad
al-Majidi, Suad Muhammad Husayn
المصدر
العدد
المجلد 56، العدد 4A (31 ديسمبر/كانون الأول 2015)، ص ص. 2732-2744، 13ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
العراق
عدد الصفحات
13
التخصصات الرئيسية
الموضوعات
الملخص EN
This research includes synthesis of new heterocyclic derivatives of N-benzyl-5-bromoisatin.
New 1, 2, 4-triazole, oxazoline and thiazoline derivatives of [N-benzyl-5-bromo-3-(Ethyliminoacetate)-indole-2-one] (2) have been synthesized.
The preparation process started by the reaction of 5-bromoisatin with sodium hydride in dimethylformamide (DMF) at 0°C, gave suspension of sodium salt of 5-bromoisatin and subsequent reaction with benzylchloride to give N-benzyl-5-bromoisatin (1).
Compound (1) reacted with ethylglycinate (Schiff base) obtained the intermediate compound (2) which reacted with different reagents in two ways.
The first way, compound (2) reacted with (hydrazine hydrate, semicarbazide, phenylsemicarbazide and thiosemicarbazide), then converted to (hydrazide, semicarbazide, phenylsemicarbazide and thiosemicarbazide) derivatives respectively to give compounds (3-6).
After that compounds (4-6) cyclized in presence of alkaline media (4N-NaOH) to form substituted 1, 2, 4-triazole derivatives (7-9).
In alkaline media (20%KOH) compound (3) reacted with CS2 to give potassium salt (10) that reacted with excess of hydrazine hydrate to give compound (11).
The second way includes reaction of compound (3) with (phenylisocyanate and phenylisothiocyanate) to give compound (5 and 12), which undergo cyclization with p-bromophenacylbromide to obtain oxazoline (13) and thiazoline (14).
Newly synthesized compounds were identified via spectral methods; their [FTIR and some of them by 1HNMR, 13C-NMR] and measurements of some of its physical properties and also some specific reactions.
Furthermore the effects of the synthesized compounds were studied on some strains of bacteria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Adhami, Huda Jamal Ahmad& al-Majidi, Suad Muhammad Husayn. 2015. Synthesis, Identification and evaluation of antibacterial activity of some new substituted N-benzyl-5-Bromo Isatin. Iraqi Journal of Science،Vol. 56, no. 4A, pp.2732-2744.
https://search.emarefa.net/detail/BIM-651422
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Adhami, Huda Jamal Ahmad& al-Majidi, Suad Muhammad Husayn. Synthesis, Identification and evaluation of antibacterial activity of some new substituted N-benzyl-5-Bromo Isatin. Iraqi Journal of Science Vol. 56, no. 4A (2015), pp.2732-2744.
https://search.emarefa.net/detail/BIM-651422
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Adhami, Huda Jamal Ahmad& al-Majidi, Suad Muhammad Husayn. Synthesis, Identification and evaluation of antibacterial activity of some new substituted N-benzyl-5-Bromo Isatin. Iraqi Journal of Science. 2015. Vol. 56, no. 4A, pp.2732-2744.
https://search.emarefa.net/detail/BIM-651422
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 2743-2744
رقم السجل
BIM-651422
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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