Xenotropic murine leukemia virus-related virus and RNase L R462Q variants in Iranian patients with sporadic prostate cancer
المؤلفون المشاركون
Ahmadi, Ali
Babaei, Farhad
Ridai, Farhad
Jalilvand, Sumayyah
Abiri, Ramin
Kunduri, Nasim
Azad, Talat Mukhtari
Mahmudi, Mahmud
Ghavami, Nastaran
Nategh, Rakhshandeh
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 17، العدد 12 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Although several studies have confirmed the association of xenotropic murine leukemia virus-related virus (XMRV) and prostate cancer, this association is still controversial, as most studies did not detect XMRV in prostate tissue samples.
Furthermore, some genetic and epidemiological studies have highlighted a role for RNase L polymorphisms, particularly R462Q, in the progression of prostate cancer.
Objectives : The focus of this study was on the association of XMRV and RNase L R462Q variants with the risk of prostate cancer in Iranian patients.
Patients and Methods: In this case-control study, 40 and 80 individuals with sporadic prostate cancer and benign prostatic hyperplasia, respectively, were included.
The presence of XMRV was evaluated by real-time polymerase chain reaction (PCR) of integrase and nested-PCR for the gag genes.
The RNase L R462Q polymorphism analysis was carried out by PCR and sequencing.
Results : In a total of 40 sporadic prostate cancer and 80 benign prostatic hyperplasia cases, no XMRV was detected by real-time PCR and nested-PCR.
RNase L R462Q polymorphism analysis reveals that although there was an increase in the risk of prostate cancer correlated with the Q/Q allele of RNase L at position 462, the frequencies of the RNase L R462Q alleles were not statistically significant between the prostate cancer and benign prostatic hyperplasia groups (OR = 2.75 (95 % CI = 0.67 - 11.3), P = 0.29).
Conclusions : These results did not support the presence of XMRV in the samples with prostate cancer and showed that RNase L R462Q variants had relatively little or no impact on the risk of prostate cancer in Iranian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Babaei, Farhad& Ahmadi, Ali& Ridai, Farhad& Jalilvand, Sumayyah& Ghavami, Nastaran& Mahmudi, Mahmud…[et al.]. 2015. Xenotropic murine leukemia virus-related virus and RNase L R462Q variants in Iranian patients with sporadic prostate cancer. Iranian Red Crescent Medical Journal،Vol. 17, no. 12, pp.1-5.
https://search.emarefa.net/detail/BIM-652356
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Babaei, Farhad…[et al.]. Xenotropic murine leukemia virus-related virus and RNase L R462Q variants in Iranian patients with sporadic prostate cancer. Iranian Red Crescent Medical Journal Vol. 17, no. 12 (Dec. 2015), pp.1-5.
https://search.emarefa.net/detail/BIM-652356
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Babaei, Farhad& Ahmadi, Ali& Ridai, Farhad& Jalilvand, Sumayyah& Ghavami, Nastaran& Mahmudi, Mahmud…[et al.]. Xenotropic murine leukemia virus-related virus and RNase L R462Q variants in Iranian patients with sporadic prostate cancer. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 12, pp.1-5.
https://search.emarefa.net/detail/BIM-652356
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4-5
رقم السجل
BIM-652356
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر