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Efficacy of tiotropium bromide and rehabilitation treatment on pulmonary function of patients with sulfur mustard lung injury
المؤلفون المشاركون
Jalili, Maryam
Afshar, Homa
Najafian, Bita
Qazvini, Ali
Zayri, Meysam
Harandi, Ali Amini
Ghani, Mustafa
Shuhrati, Majid
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 17، العدد 12 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Chronic pulmonary complication is the most common delayed toxic effect of sulfur mustard (SM) and it has no treatment so far.
Objectives : To evaluate short-term therapeutic effects of inhaled tiotropium bromide and pulmonary rehabilitation on pulmonary function of patients with SM induced lung injury.
Patients and Methods : In a randomized clinical trial, using convenient sampling method, 54 patients with chronic lung disease due to SM exposure were recruited in Baqiyatallah General Hospital, Tehran, Iran for a period of 2-month study.
They were randomly divided into 3 groups of 18 participants each.
Group 1 received routine drugs (Serevent, Flixotide), pulmonary rehabilitation 30 minutes/2 times a week, and tiotropium bromide 18 μg/day.
Group 2 was treated with routine drugs and pulmonary rehabilitation and group 3 was only on the routine drugs.
cardiopulmonary exercise test (CPET), plethysmographic measurements, and respiratory symptoms evaluation were performed before and after medical intervention.
Results: In group 1, compared to group 3, significant differences were found with regard to symptoms of cough ([difference between the first and last visit in group 1: Diff 1] = -1.6, Diff 3 = -0.3, P = 0.01) and nocturnal dyspnea (Diff 1 = -1.9, Diff 3 = 0.0, P = 0.01), likewise, compared to group 2, significant differences were found with regard to lung function parameters of forced vital capacity (Diff 1 = 3.0, Diff 2 = -3.5, P = 0.03), forced expiratory volume in one second (Diff 1 = 3.9, Diff 2 = -5.6, P = 0.009), maximal mid-expiratory flow rate 25% - 75% (Diff 1 = 1.5, Diff 2 = -3.2, P = 0.007) and peak expiratory flow (Diff 1 = -2.06, Diff 2 = -4.3, P = 0.04).
Total lung capacity (Diff 2 = 9.28, Diff 3 = -12.07, P = 0.02) and residual volume (Diff2 = 32.1, Diff3 = -27.6, P = 0.04) were increased in group 2 compared to group 3.
There were no significant differences with regard to CPET results among all groups (P > 0.05).
Conclusions : Inhalation of tiotropium bromide in combination with pulmonary rehabilitation could improve some plethysmographic lung volumes and clinical outcomes in patients with chronic pulmonary disease due to SM.
Short-term prescription of pulmonary rehabilitation has no effect on CPET of patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shuhrati, Majid& Jalili, Maryam& Afshar, Homa& Najafian, Bita& Qazvini, Ali& Zayri, Meysam…[et al.]. 2015. Efficacy of tiotropium bromide and rehabilitation treatment on pulmonary function of patients with sulfur mustard lung injury. Iranian Red Crescent Medical Journal،Vol. 17, no. 12, pp.1-6.
https://search.emarefa.net/detail/BIM-652398
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shuhrati, Majid…[et al.]. Efficacy of tiotropium bromide and rehabilitation treatment on pulmonary function of patients with sulfur mustard lung injury. Iranian Red Crescent Medical Journal Vol. 17, no. 12 (Dec. 2015), pp.1-6.
https://search.emarefa.net/detail/BIM-652398
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shuhrati, Majid& Jalili, Maryam& Afshar, Homa& Najafian, Bita& Qazvini, Ali& Zayri, Meysam…[et al.]. Efficacy of tiotropium bromide and rehabilitation treatment on pulmonary function of patients with sulfur mustard lung injury. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 12, pp.1-6.
https://search.emarefa.net/detail/BIM-652398
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6
رقم السجل
BIM-652398
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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