Atorvastatin therapy is associated with a decrease in inflammatory response and organ dysfunction in septic patients
المؤلفون المشاركون
al-Jundi, Hana A.
Ulaywah, Jamal M.
al-Shafii, Muhammad M.
Kurra, Alaa A.
المصدر
Ain Shams Journal of Anesthesiology
العدد
المجلد 6، العدد 2 (30 مايو/أيار 2013)، ص ص. 198-202، 5ص.
الناشر
جامعة عين شمس كلية الطب قسم التخدير
تاريخ النشر
2013-05-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background Sepsis is associated with a hyperactive inflammatory system, leading to an overproduction of proinflammatory mediators that contribute toward septic shock, multiple organ failure, and death.
As statins have anti-inflammatory properties that are independent of their lipid-lowering abilities, we hypothesized that septic patients may benefit from atorvastatin treatment.
Patients and methods In this prospective study, 60 adult patients were admitted to the ICU, with early sepsis criteria.
Patients were randomly assigned to two groups: an atorvastatin group that received 40 mg atorvastatin for 10 days and a control group (statin free).
The primary outcomes were the time of decrease in C-reactive protein, interleukin 6 levels, and white blood cells count and the secondary outcomes were hemodynamic variables, organ dysfunction, and failure that were defined by the sequential organ failure assessment score and hospital mortality from any cause during the study period (10 days).
Results The atorvastatin group had highly significantly lower white blood cells counts, interleukin 6, C-reactive protein, and sequential organ failure assessment scores (Po0.001) compared with the control group.
However, there was no significant difference between both groups in hemodynamic variables and mortality (P40.05) during the study period.
Conclusion Atorvastatin ameliorates the inflammatory response in septic patients and may improve the short-term outcome
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kurra, Alaa A.& al-Jundi, Hana A.& Ulaywah, Jamal M.& al-Shafii, Muhammad M.. 2013. Atorvastatin therapy is associated with a decrease in inflammatory response and organ dysfunction in septic patients. Ain Shams Journal of Anesthesiology،Vol. 6, no. 2, pp.198-202.
https://search.emarefa.net/detail/BIM-652874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kurra, Alaa A.…[et al.]. Atorvastatin therapy is associated with a decrease in inflammatory response and organ dysfunction in septic patients. Ain Shams Journal of Anesthesiology Vol. 6, no. 2 (May. 2013), pp.198-202.
https://search.emarefa.net/detail/BIM-652874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kurra, Alaa A.& al-Jundi, Hana A.& Ulaywah, Jamal M.& al-Shafii, Muhammad M.. Atorvastatin therapy is associated with a decrease in inflammatory response and organ dysfunction in septic patients. Ain Shams Journal of Anesthesiology. 2013. Vol. 6, no. 2, pp.198-202.
https://search.emarefa.net/detail/BIM-652874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 202
رقم السجل
BIM-652874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر