A contribution to covariate adaptive randomization

الملخص EN

Adaptive randomization designs are statistical designs that are used as alternative to pure randomization designs in clinical trials, with the object of reducing imbalance in trials.A new method,to be called critical percentage method (CPM) is introduced and compared with the pure randomization method through a simulation experiment.

The simulation showed that, the CPM has minimum imbalance, for all sample sizes (10, 100 and 1000).