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HLA-DRB1typing among type i diabetic patients and their first degree relatives in a comparative study
العناوين الأخرى
تحديد نوع الألليل النسجي (HLA-DRB1) في كم من مرضى السكري النوع الأول و الأقارب من الدرجة الأولى في دراسة مقارنة
المؤلفون المشاركون
al-Kabi, Muhammad Ali S.
al-Kabi, Karim Tamir
al-Iqabi, Husayn Adnan
al-Musawi, Jafar Kazim
المصدر
Kufa Journal for Nursing Sciences
العدد
المجلد 5، العدد 3 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
العراق
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Background: The genetic susceptibility to IDDM maps to the MHC class II region, thus one approach to investigating the immunopathogenesis of diabetes is to study first degree relatives of affected individuals.
Objectives: To detect the inherited relationship between (HLA-DRB1)allels and type one Diabetic mellitus.
Material and Method: A case-control study was performed on 90 persons, they divided into three group which are diabetic, siblings and control (30 persons in each group), who attended to Al Zahraa Teaching Hospital /Diabetic Center in Al Kut/Iraq between the period from April; 2012 till April; 2013.data was analyzed by using SPSS 16th version.
Distribution of HLA-DRB1 loci among the study groups (type 1 Diabetic patients, Siblings and Control group) were performed using MR.SPOT ROBOTING system, results: results showed that the frequencies of HLA-DRB1*3,*4 {25 (69.4%)} among Diabetic group were Significant (P value = 0.002), in compare to the corresponding frequencies among control group {11 (30.6%)}, in compare to the frequencies of other HLA-DRB1 loci in both Diabetic group and Control group { 15 (34.1%), 29 (65.9%)} respectively.
Meanwhile results have showed that there were no Significant (P value = 0.116), in the frequencies of HLA-DRB1*3,*4 {25 (58.1%)} among Diabetic group in compare to the frequencies of HLA-DRB1*3,*4 {18 (41.9%)} among Siblings group, in compare to the frequencies of other HLA-DRB1 loci among Diabetic group and Sibling group {15 (40.5%), 22 (59.5%)} respectively, also results have showed that there were no Significant (P value = 0.104), in the frequencies of HLA-DRB1*3,*4 {18 (62.1%)} among Sibling group in compare to the frequencies of HLA-DRB1*3,*4 {11 (37.9%)} among Control group, in compare to the frequencies of other HLA-DRB1 loci among Sibling group and Control group {22 (43.1%), 29 (56.9%)} respectively .conclusion: In conclusion there were a genetic predisposition of diabetic Siblings for development of Diabetes since, both Diabetic group and Sibling group showing the highest frequencies of HLA-DRB1 *3,*4, in compare to Control group.
Recommendation: larger sample group are required to include other allels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Kabi, Muhammad Ali S.& al-Iqabi, Husayn Adnan& al-Kabi, Karim Tamir& al-Musawi, Jafar Kazim. 2015. HLA-DRB1typing among type i diabetic patients and their first degree relatives in a comparative study. Kufa Journal for Nursing Sciences،Vol. 5, no. 3, pp.1-16.
https://search.emarefa.net/detail/BIM-655578
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Kabi, Muhammad Ali S.…[et al.]. HLA-DRB1typing among type i diabetic patients and their first degree relatives in a comparative study. Kufa Journal for Nursing Sciences Vol. 5, no. 3 (Sep. / Dec. 2015), pp.1-16.
https://search.emarefa.net/detail/BIM-655578
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Kabi, Muhammad Ali S.& al-Iqabi, Husayn Adnan& al-Kabi, Karim Tamir& al-Musawi, Jafar Kazim. HLA-DRB1typing among type i diabetic patients and their first degree relatives in a comparative study. Kufa Journal for Nursing Sciences. 2015. Vol. 5, no. 3, pp.1-16.
https://search.emarefa.net/detail/BIM-655578
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 13-16
رقم السجل
BIM-655578
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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