Role of superoxide dismutase enzyme in patients with epilepsy

الملخص EN

Epilepsy is a disease of the brain in which at least two unprovoked (or reflex) seizures occurring within more than 24 hours apart Epilepsy is classified to idiopathic, cryptogenic, and mixed classification.Superoxide dismutase (SOD) ; an enzyme that catalyzes the dismutation of superoxide radicals have been purified by a simple procedure from bovine erythrocytes.

This enzyme contains 2 equivalent of copper per mole of enzyme.The aim of the study to know the significance of antioxidant superoxide dismutase (SOD) enzyme in epileptic patients.

This is a prospective study conducted in Al-Hussein Teaching Hospital in Holy Kerbalaa for the period from January to October 2014 .One hundred ten (110) patients were included in this study.Superoxide dismutase activityis determined by using a simple and rapid method.

Superoxide dismutase enzyme level in epileptic patients was significantly lower (p < 0.01) than its level in healthy control.

It was significantly lower in all subgroups of patients when compared to control subgroups (p < 0.01).It was significantly lower in patients group in both male and female when compared to control group (p < 0.01).

Epilepsy is linked with the defect in the antioxidant defense mechanism.