Evaluation of oxidative stress status and some biochemical change in adult obese individuals in Hilla City

الملخص EN

Obesity is a rapidly growing epidemic worldwide, influenced by both genetic and environmental factors.

The onset of obesity is due mainly to low energy expenditure (such as from exercise) combined with high caloric intake.

The study was conducted on fifty obese individuals and fifty apparently healthy control individuals; the age was between (18-60) years.

Blood samples obtained from Marjan Medical City in Babylon Province.

The aim of this study to evaluate the differences of oxidant malondialdehyde (MDA), antioxidantenzyme superoxide dismutase (SOD),catalase (CAT), glutathione peroxidase (GPx), insulin resistance (IR) and lipid profile in sera of adult obese individuals and the control group.

The results of present study revealed a significant increase in MDA (p<0.001), blood glucose (p<0.001), insulin (p<0.001), insulin resistance (p<0.001), total cholesterol (p<0.05), TG (p<0.001), VLDL-cholesterol (p < 0.001) and LDL-cholesterol (p < 0.001) concentration in sera of obese individuals whencompared to those of the control group.

Also this study show significant decrease in SOD (p < 0.001), CAT (p < 0.001), GPx (p < 0.001) and HDL-C (p < 0.05) concentration in sera of obese individualswhen compared to those of the control group.

The study concluded that obesity is associated with increase oxidative stress.

The increase of MDA concentration and decrease of SOD, CAT and GPxconcentration may contribute in the development of complications of obesity.