Association of erythrocytes antioxidant enzymes and their cofactors with markers of oxidative stress in patients with sickle cell anemia
المؤلفون المشاركون
Hasan, Muayyad K.
Mahdi, Jawad K.
al-Nimah, Lamya Muhammad
المصدر
العدد
المجلد 24، العدد 2 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
قطر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
- الإجهاد التأكسدي
- المرضى
- الخلايا المنجلية
- العراق
- خلايا الدم
- المضاعفات(الطب)
- مضادات الأكسدة
- كريات الدم الحمراء
الملخص EN
Background: Sickle cell anemia (SCA) is an inherited blood disease with known complications as a result of certain pathophysiological dysfunctions.
It has been suggested that an increase in oxidative stress contributes to the incidence of these changes.
Objectives: This study investigated the oxidant/ antioxidant status of patients with SCA, and evaluated the effect of SCA on antioxidant enzymes and their cofactors.
Methods: The study included 42 patients with SCA (in steady state), and a control group of 50 age-matched individuals without SCA.
Serum malondialdehyde (MDA), copper, zinc, ferritin and iron levels, red blood cell (RBC) superoxide dismutase (SOD) and catalase levels were measured for the SCA and control groups.
Results: Significantly lower levels of antioxidant enzymes (RBC SOD and catalase) and higher serum MDA levels (biomarker of oxidative stress) were found in SCA patients compared to the control group (all p , 0.001).
Increased levels of serum ferritin, iron and copper and decreased zinc concentrations were also found in the SCA patients compared to the control group (all p , 0.001).
In the SCA group, there were significant negative correlations between MDA levels and RBC SOD, RBC catalase, and serum zinc levels (p , 0.01), while a significant positive correlation between MDA with serum copper and iron levels (p , 0.01) was observed.
Conclusion: SCA is associated with alterations in markers of oxidative stress including an increased MDA level, decreased antioxidant enzyme levels, and altered levels of enzyme cofactors (zinc, copper, and iron).
This suggests that these antioxidant enzymes could be used as effective therapeutic targets for the treatment of this disease and supplementation of patients with substances with antioxidant properties may reduce the complications of this disease.
Keywords: malondialdehyde, superoxide dismutase, catalase, sickle cell anemia, oxidative stress, enzymes cofactors
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Nimah, Lamya Muhammad& Hasan, Muayyad K.& Mahdi, Jawad K.. 2015. Association of erythrocytes antioxidant enzymes and their cofactors with markers of oxidative stress in patients with sickle cell anemia. Qatar Medical Journal،Vol. 24, no. 2, pp.1-10.
https://search.emarefa.net/detail/BIM-656698
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Nimah, Lamya Muhammad…[et al.]. Association of erythrocytes antioxidant enzymes and their cofactors with markers of oxidative stress in patients with sickle cell anemia. Qatar Medical Journal Vol. 24, no. 2 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-656698
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Nimah, Lamya Muhammad& Hasan, Muayyad K.& Mahdi, Jawad K.. Association of erythrocytes antioxidant enzymes and their cofactors with markers of oxidative stress in patients with sickle cell anemia. Qatar Medical Journal. 2015. Vol. 24, no. 2, pp.1-10.
https://search.emarefa.net/detail/BIM-656698
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-10
رقم السجل
BIM-656698
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر