The role of serum surfactant protein D as a biomarker of exacerbation of chronic obstructive pulmonary disease
المؤلفون المشاركون
al-Abidin, Ala Zayn
Muhammad, Yussir
Fahum, Sahar
المصدر
العدد
المجلد 24، العدد 2 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
قطر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: The exacerbation of chronic obstructive pulmonary disease (COPD) is a major factor for the high mortality associated with the disease.
There is a paucity in the lung-specific biomarkers which diagnose these exacerbations.
Surfactant protein D (SP-D) is a promising biomarker in predicting clinical outcomes for patients with COPD, is lung-specific and can be detected in serum.
However, the profile in which serum concentrations of SP-D change during acute exacerbation is still unclear.
This study aims to estimate and compare the concentrations of serum SP-D in patients with stable disease and during the exacerbation.
Methods: A cross-sectional study was conducted which composed of apparently healthy individuals (n ¼ 28), which included 14 smokers and 14 nonsmokers, patients with stable COPD (n ¼ 28), and patients experiencing acute exacerbations (n ¼ 28).
Pulmonary functions were performed for all groups.
Serum SP-D concentrations were measured using enzyme-linked immunosorbent assay (ELISA).
These concentrations were compared by analysis of variance.
Results: Serum SP-D levels were significantly elevated in patients with acute exacerbations (508.733 ^ 102.813 ng/ml) compared to patients with stable COPD (337.916 ^ 86.265 ng/ml) and healthy subjects (177.313 ^ 46.998 ng/ml; p , 0.001).
Serum SP-D levels correlated inversely with lung function parameters including FEV1%pred, FVC%pred and FEV1/FVC.
Conclusion: Serum SP-D levels are raised early on during acute exacerbations of COPD, which could be a potential early diagnostic biomarker for COPD exacerbations Keywords: chronic obstructive pulmonary disease (COPD), serum biomarker, COPD exacerbations, COPD diagnosis, surfactant protein D (SP-D)
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Abidin, Ala Zayn& Muhammad, Yussir& Fahum, Sahar. 2015. The role of serum surfactant protein D as a biomarker of exacerbation of chronic obstructive pulmonary disease. Qatar Medical Journal،Vol. 24, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-656729
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Abidin, Ala Zayn…[et al.]. The role of serum surfactant protein D as a biomarker of exacerbation of chronic obstructive pulmonary disease. Qatar Medical Journal Vol. 24, no. 2 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-656729
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Abidin, Ala Zayn& Muhammad, Yussir& Fahum, Sahar. The role of serum surfactant protein D as a biomarker of exacerbation of chronic obstructive pulmonary disease. Qatar Medical Journal. 2015. Vol. 24, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-656729
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-656729
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر