Radiation therapy in metastatic compression of the spinal cord : results of 8Gy x 2 fractions
المؤلفون المشاركون
al-Sawi, Wail H.
Abd al-Muttalib, Ahmad
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 14، العدد 1 (31 مارس/آذار 2002)، ص ص. 1-8، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2002-03-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : our aim was to evaluate the clinical outcome and toxicity of a short course of radiation therapy in selected patients with metastatic spinal cord compression.
Patients and methods : between September 1997 and December 1998, 35 patients with metastatic spinal cord compression from low radio-responsive primary tumors (non-small cell lung, kidney, bladder and gastrointestinal carcinomas and soft tissue sarcomas), or more radio-responsive ones (breast and prostate carcinomas, myeloma and non-Hodgkin's lymphoma) with paresis, plegia, low performance status (PS ECOG ≥ 3) and / or short life expectancy, underwent short-course of radiation therapy ; a single fraction of 8 Gy repeated after 1 week in responders or patients with stable disease for a total of 16 Gy.
Out of 35 evaluable patients, 3 (8.6 %) underwent simple laminecto-my and radiotherapy and the other 32 received radiotherapy alone.
Median follow up was 20 months (range, 7-32).
Response was assessed according to the severity of back pain and motor function and bladder capacity before and after radiotherapy.
Results : pain relief was achieved in 82.9% of patients and motor function response rate reached 71.4 %.
Early diagnosis and therapy were very important in predicting response to radiotherapy.
All but 2 (90 %) pretreatment walking patients and all but 1 (96.4 %) with good bladder function preserved these capacities.
On the contrary, when diagnosis was late, only 46.7 % of non-ambulatory patients and 42.9 % of those with bladder dysfunction improved.
Median survival was 6 months, with a 32 % probability of survival for 1 year.
Length of survival was significantly longer in patients with the ability to walk before and / or after radiotherapy.
The survival and duration of response was significantly associated with each other with no evidence of relapse in the irradiated area.
Sickness appeared only in a few cases.
Slight esophagitis was more frequent, dysphagia for solid foods was observed in 25 % of patients irradiated thoracic vertebrae.
Late toxicity was not observed.
Conclusion : The use of a single fraction of 8 Gy repeated after 1 week for a total of 16 Gy gave a clinical outcome comparable with that expected from more protracted regimens with only slight side effects.
The use of a few large treatment fractions could be explored considering the associated advantages for the patients and radiation therapy centers often overloaded by long patient waiting lists.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sawi, Wail H.& Abd al-Muttalib, Ahmad. 2002. Radiation therapy in metastatic compression of the spinal cord : results of 8Gy x 2 fractions. Journal of the Egyptian National Cancer Institute،Vol. 14, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-66820
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sawi, Wail H.& Abd al-Muttalib, Ahmad. Radiation therapy in metastatic compression of the spinal cord : results of 8Gy x 2 fractions. Journal of the Egyptian National Cancer Institute Vol. 14, no. 1 (Mar. 2002), pp.1-8.
https://search.emarefa.net/detail/BIM-66820
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sawi, Wail H.& Abd al-Muttalib, Ahmad. Radiation therapy in metastatic compression of the spinal cord : results of 8Gy x 2 fractions. Journal of the Egyptian National Cancer Institute. 2002. Vol. 14, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-66820
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-66820
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر