Validated HPTLC method for the simultaneous determination of cinnarizine and dimenhydrinate in their combined dosage form
المؤلفون المشاركون
al-Kafrawi, Dina S.
Bilal, Tariq S.
المصدر
Arab Journal of Basic and Applied Sciences
العدد
المجلد 19، العدد 0 (29 فبراير/شباط 2016)، ص ص. 15-22، 8ص.
الناشر
تاريخ النشر
2016-02-29
دولة النشر
البحرين
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A simple, rapid and selective high performance thin layer chromatography (HPTLC) method was developed for the simultaneous determination of cinnarizine (CNZ) and dimenhydrinate (DMH) in pure form and in their combined dosage form.
Reviewing the literature revealed that there are no reports for the use of TLC for the assay of this mixture.
Effective separation was achieved using Fluka HPTLC aluminum sheets of silica gel 60 F254 using chloroform–n-hexane– methanol (8.5:0.8:0.7, by volume) as mobile phase, followed by densitometric measurement of CNZ and DMH spots at 254 and 279 nm, respectively.
The reliability and analytical performance of the proposed HPTLC method were statistically validated with respect to linearity, ranges, precision, accuracy, selectivity, robustness and detection and quantification limits.
Calibration curves were linear in the ranges of 50–400 and 50–500 ng/spot for CNZ and DMH, respectively with correlation coefficients >0.9998.
The limits of detection were 8.1 and 8.0 ng/spot for CNZ and DMH respectively.
The validated HPTLC method was applied to the simultaneous analysis of CNZ and DMH in laboratory-prepared tablets.
Both analytes were successfully quantified with good recovery values, and no interference was encountered from the inactive ingredients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Kafrawi, Dina S.& Bilal, Tariq S.. 2016. Validated HPTLC method for the simultaneous determination of cinnarizine and dimenhydrinate in their combined dosage form. Arab Journal of Basic and Applied Sciences،Vol. 19, no. 0, pp.15-22.
https://search.emarefa.net/detail/BIM-668452
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Kafrawi, Dina S.& Bilal, Tariq S.. Validated HPTLC method for the simultaneous determination of cinnarizine and dimenhydrinate in their combined dosage form. Arab Journal of Basic and Applied Sciences Vol. 19 (Feb. 2016), pp.15-22.
https://search.emarefa.net/detail/BIM-668452
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Kafrawi, Dina S.& Bilal, Tariq S.. Validated HPTLC method for the simultaneous determination of cinnarizine and dimenhydrinate in their combined dosage form. Arab Journal of Basic and Applied Sciences. 2016. Vol. 19, no. 0, pp.15-22.
https://search.emarefa.net/detail/BIM-668452
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 21-22
رقم السجل
BIM-668452
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر