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Primary brain lymphoma in immunocompetent patients-prognostic factors and treatment outcome
المؤلفون المشاركون
Shukri, Muhammad
al-Husayni, Jamal
Murad, Walid A.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 14، العدد 1 (31 مارس/آذار 2002)، ص ص. 51-58، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2002-03-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : primary brain lymphoma (PBL) is an aggressive intracranial neoplasm of lymphocytic origin that involves the brain parenchyma and meninges.
The increasing number of cases of PBL has resulted in a growing awareness of and interest in this disease and has promoted a large number of publications.
Material and methods : Twenty-nine immunocompe-tent patients with primary non-Hodgkin's lymphoma of the brain (PBL) were seen at our institute between 1975 and 1998.
Twenty-seven patients had received external radiation therapy (XRT).
The treatment volume included the whole brain (WB) in 10 patients, WB plus boost in 12 patients and the craniospinal axis in 5 cases.
The XRT dose ranged from 5.4 to 60 Gy with a median of 50 Gy.
Two patients received pre-irradiation high dose methotrexate.
One patient received intrathecal methotrexate and one had 3 cycles of adjuvant chemotherapy.
Results: The mean age at diagnosis was 53 years.
Nine patients (31%) were found to have multifocal tumors.
Eighteen patients were evaluable for assessment of treatment response.
Complete response was achieved in 13 / 18 patients (72 %), while 4 (22 %) had partial response.
Six of 13 patients (46 %) who achieved complete response relapsed.
Late neurotoxicity was reported in 9 of 15 patients who survived for more than 6 months after therapy.
With a median follow up of 24 months, the 3 and 5-year overall survival (OS) rates were 40% and 16 %, respectively.
The median survival was 1.1 year.
Age < 60 years, performance status < 4, solitary brain lesion, XRT dose > 40 Gy, WB XRT with boost and complete response to therapy were found to be associated with statistically significant higher OS rates.
Cox regression analysis indicated that performance status, response to therapy and XRT dose > 40 Gy were the most significant prognostic variables.
Conclusion : the outlook with primary brain lympho-ma in immunocompetent patients remains somewhat dismal.
Randomized trials addressing the efficacy of chemotherapy (with and without radiation) over radiation alone are needed.
New treatment approaches need to be considered in a multiinstitutional setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Husayni, Jamal& Murad, Walid A.& Shukri, Muhammad. 2002. Primary brain lymphoma in immunocompetent patients-prognostic factors and treatment outcome. Journal of the Egyptian National Cancer Institute،Vol. 14, no. 1, pp.51-58.
https://search.emarefa.net/detail/BIM-67040
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Husayni, Jamal…[et al.]. Primary brain lymphoma in immunocompetent patients-prognostic factors and treatment outcome. Journal of the Egyptian National Cancer Institute Vol. 14, no. 1 (Mar. 2002), pp.51-58.
https://search.emarefa.net/detail/BIM-67040
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Husayni, Jamal& Murad, Walid A.& Shukri, Muhammad. Primary brain lymphoma in immunocompetent patients-prognostic factors and treatment outcome. Journal of the Egyptian National Cancer Institute. 2002. Vol. 14, no. 1, pp.51-58.
https://search.emarefa.net/detail/BIM-67040
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 57-58
رقم السجل
BIM-67040
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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