Correlation between soluble cytoadhesion molecules (svcam-1 and sicam-1) with prognostic markers of disease activity in chronic b-lymphocytic leukemia (b-cll)
المؤلفون المشاركون
Hamdi, Maha Salah Al-Din
Mustafa, Ihab
Abd Al-Maqsud, Saher
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 14، العدد 4 (31 ديسمبر/كانون الأول 2002)، ص ص. 311-318، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2002-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose : to investigate the potential usefulness of sVCAM-1 and sICAM-1 in morphologically and immu-nophenotypically confirmed B-CLL as prognostic markers in newly diagnosed patients and to guide in selecting a treatment protocol.
Patients and Methods : the study included 27 newly diagnosed B-CLL patients, in different stages, according to modified Rai classification.
Fifteen age and sex matched healthy volunteers were included as a control group.
Diagnosis was made in all cases by examination of Leish-man-stained peripheral blood and bone marrow smears and was confirmed by phenotypic analysis that was performed on the “Epics profile II” flow cytometer using fluorescein isothiocyanate and phycoerythrin-labeled monoclonal antibodies.
Serum levels of sVCAM-1 and sICAM-1 were measured by the ELISA technique.
Eighteen out of the 27 patients with elevated sVCAM-1 level were treated with chlorambucil or cyclophosphamide and prednisone.
Follow up of the cases was done by serial estimations of sVCAM-1 levels in both treated and untreated patients at 3 month-intervals for one year.
Results : both sVCAM-1 and sICAM-1 were well correlated with clinical staging, i.e.
B-CLL patients representing high risk stages had significantly higher (p < 0.001) serum levels of sVCAM-1 and sICAM-1 compared with intermediate risk and low risk patients.
However, sVCAM-1 was more superior and closely reflected the tumor burden in B-CLL than sICAM-1 as it was strongly correlated with clinical staging, lymphocyte count and β2-microglobulin level.
In the treated group, during the follow up period, 12 patients showed progressive decline of sVCAM-1 and 10 of them remained alive for the whole time of follow up, whereas the remaining 6 patients showed, more or less, a stationary level of sVCAM-1 and four of them died from disease complications.
In the untreated group, 5 patients who had the highest levels of sVCAM-1 progressed rapidly to more advanced stages of the disease and developed complications.
Conclusion : sVCAM-1 is a more sensitive prognostic marker than sICAM-1 as it significantly correlates with tumor burden and serum markers.
Moreover, sVCAM-1 measurement is easy, reproducible and accurate and can be used as a laboratory tool for deciding a treatment or no treatment policy for patients in early stages of the disease.
This needs to be more confirmed in prospective studies on larger numbers of patients and longer follow-up periods.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hamdi, Maha Salah Al-Din& Mustafa, Ihab& Abd Al-Maqsud, Saher. 2002. Correlation between soluble cytoadhesion molecules (svcam-1 and sicam-1) with prognostic markers of disease activity in chronic b-lymphocytic leukemia (b-cll). Journal of the Egyptian National Cancer Institute،Vol. 14, no. 4, pp.311-318.
https://search.emarefa.net/detail/BIM-67495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hamdi, Maha Salah Al-Din…[et al.]. Correlation between soluble cytoadhesion molecules (svcam-1 and sicam-1) with prognostic markers of disease activity in chronic b-lymphocytic leukemia (b-cll). Journal of the Egyptian National Cancer Institute Vol. 14, no. 4 (Dec. 2002), pp.311-318.
https://search.emarefa.net/detail/BIM-67495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hamdi, Maha Salah Al-Din& Mustafa, Ihab& Abd Al-Maqsud, Saher. Correlation between soluble cytoadhesion molecules (svcam-1 and sicam-1) with prognostic markers of disease activity in chronic b-lymphocytic leukemia (b-cll). Journal of the Egyptian National Cancer Institute. 2002. Vol. 14, no. 4, pp.311-318.
https://search.emarefa.net/detail/BIM-67495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 227-228
رقم السجل
BIM-67495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر