Effect of cis-retinoic acid on bcl-2 and some mitochondrial enzymes in patients with acute myeloid leukemia : A randomized cytochemical study
المؤلفون المشاركون
Sadiq, Nadiyah Ali
Yusuf, Majidah Ismail
Yahya, Muna Abd al-Hamid
al-Maktari, Lutfi Abd al-Salam
المصدر
Journal of the Medical Research Institute
العدد
المجلد 27، العدد 2 (30 يونيو/حزيران 2006)، ص ص. 152-156، 5ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2006-06-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Cis retinoic acid (Cis-RA) is one of the retinoids, which induce growth arrest and apoptosis in acute myeloblastic leukemia (AML(.
Aim : The present work aimed to investigate whether Cis-RA- induced apoptosis in AML is related to changes in BcL-2 oncoprotein and some mitochondrial enzymes, notably cytochrome C oxidase and adenosine triphosphatase (ATPase) in patients with acute myeloid leukemia (AML).
Methods: Thirty patients with AML were enrolled in the study.
Ten healthy individuals served as control.
Bone marrow smears were collected before and after chemotherapy, cyto-chemistry for cytochrome C oxidase and ATPase and immunocytochemistry of Bcl-2 were done.
Results : The present work revealed that the cytochrome C oxidase activity was reduced in patients before chemotherapy compared to the control.
while, it was strong after chemotherapy (with or without Cis-RA) reflecting apoptosis.
Weak ATPase activity was found in patients versus the control due to its depletion.
Bcl-2 was overexpressed in patients versus the control, decreased after chemotherapy, especially in patients who received Cis-RA and remained high in patients exhibiting drug resistance.
A significant reduction of bcl-2 (P<0.001) paralleled with a significantly positive reaction of cytochrome C oxidase (P<0.001).
Conclusions : It is concluded that Cis-RA reduces Bcl-2 activity and increases the release of cytochrome C oxidase with depletion of ATPase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yusuf, Majidah Ismail& Yahya, Muna Abd al-Hamid& Sadiq, Nadiyah Ali& al-Maktari, Lutfi Abd al-Salam. 2006. Effect of cis-retinoic acid on bcl-2 and some mitochondrial enzymes in patients with acute myeloid leukemia : A randomized cytochemical study. Journal of the Medical Research Institute،Vol. 27, no. 2, pp.152-156.
https://search.emarefa.net/detail/BIM-67601
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yusuf, Majidah Ismail…[et al.]. Effect of cis-retinoic acid on bcl-2 and some mitochondrial enzymes in patients with acute myeloid leukemia : A randomized cytochemical study. Journal of the Medical Research Institute Vol. 27, no. 2 (2006), pp.152-156.
https://search.emarefa.net/detail/BIM-67601
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yusuf, Majidah Ismail& Yahya, Muna Abd al-Hamid& Sadiq, Nadiyah Ali& al-Maktari, Lutfi Abd al-Salam. Effect of cis-retinoic acid on bcl-2 and some mitochondrial enzymes in patients with acute myeloid leukemia : A randomized cytochemical study. Journal of the Medical Research Institute. 2006. Vol. 27, no. 2, pp.152-156.
https://search.emarefa.net/detail/BIM-67601
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 155-156
رقم السجل
BIM-67601
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر