Prognostic significance of C1q deposition in serial biopsies for predicating the long-term outcome in patients with proliferative lupus nephritis
المؤلفون المشاركون
al-Awdah, Nurah
Suwayda, Abd al-Karim
Husayn, Sufia
Ullah, Anhar
Kafuri, Halah
al-Ghunaym, Muhammad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 27، العدد 2 (30 إبريل/نيسان 2016)، ص ص. 305-311، 7ص.
الناشر
تاريخ النشر
2016-04-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Lupus nephritis (LN) is characterized by a highly variable clinical course.
It has been reported that histopathologic lesions are risk factors for the progression of LN.
The aim of this study is to investigate the relationship among the co-deposition of C1q, clinicopathological features, and renal outcomes in patients with LN.
The clinical and histological parameters were studied in patients with International Society of Nephrology/Renal Pathology Society Class III or IV LN, who underwent two kidney biopsies.
The patients were divided into two groups based on the glomerular C1q deposits: C1q-positive and C1q-negative.
The impact of C1q status and longterm renal outcome on the doubling of serum creatinine and the rate of remission in the two groups were further investigated.
Fifty-three patients had pure proliferative nephritis and 37.7% of these had a co-deposition of C1q.
Doubling of serum creatinine was observed in 25% of patients with C1q-positive and 24.2% of patients with C1q-negative deposits.
There was no difference between the two groups in terms of achieving complete or partial remission.
The renal survival in the two groups was similar (P = 0.75).
Upon repeat biopsy, the persistence of C1qpositivity was associated with a poor outcome (P = 0.007).
C1q deposition in the glomerulus in the baseline biopsy was not associated with a poor renal outcome or severe pathologic features in patients with proliferative LN.
However, the persistence of C1q positivity in repeat kidney biopsy is associated with a poor renal outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Suwayda, Abd al-Karim& Husayn, Sufia& al-Ghunaym, Muhammad& al-Awdah, Nurah& Ullah, Anhar& Kafuri, Halah. 2016. Prognostic significance of C1q deposition in serial biopsies for predicating the long-term outcome in patients with proliferative lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 2, pp.305-311.
https://search.emarefa.net/detail/BIM-677958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Suwayda, Abd al-Karim…[et al.]. Prognostic significance of C1q deposition in serial biopsies for predicating the long-term outcome in patients with proliferative lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 2 (Mar. / Apr. 2016), pp.305-311.
https://search.emarefa.net/detail/BIM-677958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Suwayda, Abd al-Karim& Husayn, Sufia& al-Ghunaym, Muhammad& al-Awdah, Nurah& Ullah, Anhar& Kafuri, Halah. Prognostic significance of C1q deposition in serial biopsies for predicating the long-term outcome in patients with proliferative lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 2, pp.305-311.
https://search.emarefa.net/detail/BIM-677958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 310-311
رقم السجل
BIM-677958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر