Natural killer cells enhance the immune surveillance of cancer
المؤلفون المشاركون
Nuruz, Faysal
Nurin, Shumaylah
Bibi, Farzana
Masud, Nushin
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 17، العدد 2 (30 إبريل/نيسان 2016)، ص ص. 149-154، 6ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2016-04-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Immune system (IS) is comprised of molecules, cells, tissues and organs involved in host defense mechanism from infectious agents or tumor cells.
On crossing the cell barriers by these infectious agents, the defense mechanism is alerted by the immune system to respond against these invading microbes.
Innate immune response (IIR) and acquired immune response (AIR) are working in parallel to control these invading microbes.
IIR is composed of various types of phagocytes and lymphocytes, while AIR is comprised of T and B lymphocytes.
All the cells of the immune system cooperatively work against infectious agents and cancerous cells but Natural killer (NK) cells are playing an important role to respond to tumor by enhancing the expression of complementary domain (CD86) on dendritic cells (DCs) and production of IL-12.
NK cells demolished tumor through perforin and granzyme, which are important for immune surveillance and death of tumor cells induced by cytokines such as tumor necrosis factor (TNF), Fas ligand (CD178), interferon-c (IFN-c) and IL-10.
These cytokines have inhibited proliferation of tumor by inducing antiangiogenic factors and maintaining cross talk with other immune cells.
Natural products like transfer factor plus, immune modulator mix, ascorbic acid, Ganoderma lucidum, Agaricus blazei teas, nitrogenated soy extract, Andrographis paniculata and several phytochemicals enhanced the efficiency of NK cells in controlling cancers.
Further studies will unravel the impact of NK cells in cancer control and how NK efficiency can be further enhanced.
2015 The Authors.
Production and hosting by Elsevier B.V.
on behalf of Ain Shams University.
This is an open access article under theCCBY-NC-NDlicense
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nuruz, Faysal& Bibi, Farzana& Nurin, Shumaylah& Masud, Nushin. 2016. Natural killer cells enhance the immune surveillance of cancer. The Egyptian Journal of Medical Human Genetics،Vol. 17, no. 2, pp.149-154.
https://search.emarefa.net/detail/BIM-679309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nuruz, Faysal…[et al.]. Natural killer cells enhance the immune surveillance of cancer. The Egyptian Journal of Medical Human Genetics Vol. 17, no. 2 (Apr. 2016), pp.149-154.
https://search.emarefa.net/detail/BIM-679309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nuruz, Faysal& Bibi, Farzana& Nurin, Shumaylah& Masud, Nushin. Natural killer cells enhance the immune surveillance of cancer. The Egyptian Journal of Medical Human Genetics. 2016. Vol. 17, no. 2, pp.149-154.
https://search.emarefa.net/detail/BIM-679309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 153-154
رقم السجل
BIM-679309
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر