Detection of novel chromosomal abnormalities in bilharzial bladder cancer by comparative genomic hybridization
المؤلفون المشاركون
Manoir, Stanislass Du
Khalid, Husayn M.
Bahnasi, Abir A.
Zikri, Abd al-Rahman N.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 15، العدد 1 (31 مارس/آذار 2003)، ص ص. 49-60، 12ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2003-03-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Background and Rationale : considerable evidence suggests that S.
hematobium infection plays an important role in the development of bladder cancer in Egypt.
Understanding the molecular basis of the disease may explain the reported differences in the clinic pathologic and epidemiological features between bilharzia bladder cancer (BBC) and conventional transitional cell carcinoma (CTCC) of the western countries.
Material and Methods : comparative genomic hybridization (CGH) is a valuable procedure for whole-genome scanning to detect consistent chromosomal aberrations.
CGH was used to screen for losses and gains of DNA sequences along all chromosome arms in 22 cases of BBC.
The results of CGH were confirmed by fluorescent in situ hybridization (FISH).
Results : Although most amplifications and deletions have been previously reported in CTCC such as loss at chromosomes 17 (86.36 %), Y (54.4 %), 9 (50 %) and gain of chromosomes 1 (72.7 %), 5 (31.8 %) and 7 (27 %) and gain of 13q (63.6 %), we were able to detect intriguing and uncommon aberrations in BBC that were not reported before in CTCC, such as complete and partial loss of chromosome 19 (86.36 %), 22q- (54.4 %), 15q- and iso (4q+) (40.9 % each).
Conclusion: The results of the present study demonstrate genetic differences between BBC and CTCC of the western countries.
If confirmed in an extended follow-up study, the observed differences, which might be attributed to the varied etiology, could explain the difference in course and clinical features between the two disease entities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bahnasi, Abir A.& Zikri, Abd al-Rahman N.& Khalid, Husayn M.& Manoir, Stanislass Du. 2003. Detection of novel chromosomal abnormalities in bilharzial bladder cancer by comparative genomic hybridization. Journal of the Egyptian National Cancer Institute،Vol. 15, no. 1, pp.49-60.
https://search.emarefa.net/detail/BIM-67940
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bahnasi, Abir A.…[et al.]. Detection of novel chromosomal abnormalities in bilharzial bladder cancer by comparative genomic hybridization. Journal of the Egyptian National Cancer Institute Vol. 15, no. 1 (Mar. 2003), pp.49-60.
https://search.emarefa.net/detail/BIM-67940
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bahnasi, Abir A.& Zikri, Abd al-Rahman N.& Khalid, Husayn M.& Manoir, Stanislass Du. Detection of novel chromosomal abnormalities in bilharzial bladder cancer by comparative genomic hybridization. Journal of the Egyptian National Cancer Institute. 2003. Vol. 15, no. 1, pp.49-60.
https://search.emarefa.net/detail/BIM-67940
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 59-60
رقم السجل
BIM-67940
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر