![](/images/graphics-bg.png)
Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration
المؤلفون المشاركون
Morrison, Margaret E.
Levin, Edward D.
Wells, Corinne
Rezvani, Amir H.
Slade, Susan
Marshall, Lindsey
Morris, Matt
Confino, Jamie
Allenby, Cheyenne
Lumeng, Lawrence
المصدر
Journal of Drug and Alcohol Research
العدد
المجلد 5، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2016-12-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background.
Alcohol and nicotine are commonly coabused.
The search for a common core of neural, behavioral, and genetic factors underlying addiction has been the goal of addiction research.
Purpose.
Genetic predisposition to high alcohol intake has been studied in rats by selectively breeding rats that have high preference for alcohol.
The current experiments were conducted to determine if the level of intravenous nicotine administration for the various lines of alcohol-preferring rats differs from that for nonalcohol-preferring controls.
Study design.
Adult alcohol-na¨ıve selectively-bred alcohol-preferring male rats from four lines (P, AA, HAD-1, sP) and their control nonalcohol-preferring rats (NP, ANA, LAD-1, sNP) were trained and given access to self-administer nicotine (0.03mg/kg/infusion).
Results.
The results show that the P rats selfadministered significantly more nicotine than NP rats.
In contrast, there were no significant differences in nicotine self-administration between the sP and sNP or the AA and ANA rats.
Unexpectedly, high alcohol-drinking HAD-1 rats self-administered significantly less nicotine than low alcohol-drinking LAD-1 rats.
Conclusion.
This suggests that some genetic factors that underlie high-alcohol intake have more general effects in promoting high nicotine intake tendencies, while other genetic factors are more specific to only heavy drinking
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rezvani, Amir H.& Levin, Edward D.& Wells, Corinne& Slade, Susan& Morrison, Margaret E.& Marshall, Lindsey…[et al.]. 2016. Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration. Journal of Drug and Alcohol Research،Vol. 5, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-679453
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rezvani, Amir H.…[et al.]. Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration. Journal of Drug and Alcohol Research Vol. 5 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-679453
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rezvani, Amir H.& Levin, Edward D.& Wells, Corinne& Slade, Susan& Morrison, Margaret E.& Marshall, Lindsey…[et al.]. Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration. Journal of Drug and Alcohol Research. 2016. Vol. 5, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-679453
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-9
رقم السجل
BIM-679453
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)