Association between outcomes and demographic factors in an Azeri Turkish population with cystic fibrosis : a cross-sectional study in Iran from 2001 through 2014

الملخص EN

Background: Outcomesforcystic fibrosis patients are improving rapidly.

The demographic factors are notable variables inoutcomes, which can be evaluated and modified.

Objectives: This study was designed to investigate the association between outcome and demographic factors in patients with cystic fibrosis.

Patients and Methods: This was a cross-sectional study and data were gathered for 331 patients using the census method, from March 2001 to September 2014 in Iran.

Data was analyzed using logistic regression analysis, chi-square test, and independent sample t test using SPSS 18.

Odds ratio with confidence intervals of 95% and P < 0.05 were considered significant.

Results: There were 85 (25.7%) deceased patients and 246 (74.3%) living patients at the time of the study.

Of the 246 living CF patients, 202 (82.2%) were less than nine years of age, and 77 (90.6%) out of the 85 deceased CF patients had died younger than four years of age.

There was a significant difference between outcome and location of residence.

The risk of mortality was 50% less in urban patients than in rural patients (P = 0.03).

The risk of mortality was approximately two times higher in patients with a positive family history than in those with a negative family history (P = 0.02).

The proportion of mortality was approximately two times, or 94%, higher for those in a consanguineous marriage than for those in a non-consanguineous marriage (P = 0.01).

Conclusions: The results demonstrated that the mortality rate was higher in CF patients with a positive family history, a consanguineous marriage, and residence in a rural area.

Therefore, demographic factors play an important role in the outcome of cystic fibrosis.

Unfortunately, these parameters, which can be managed easily and with low cost, have been overlooked.