Na K citrate versus sodium bicarbonate in prevention of contrast-induced nephropathy
المؤلفون المشاركون
Abu Zaid, Samih Muhammad
al-Husari, Husam E.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 27، العدد 3 (30 يونيو/حزيران 2016)، ص ص. 519-525، 7ص.
الناشر
تاريخ النشر
2016-06-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Contrast-induced nephropathy (CIN) is one of the important complications of radiographic procedures, especially in patients with chronic kidney disease.
It is also one of the common causes of acute kidney injury.
The pathogenesis is postulated to be the effect of oxygenfree radicals and hyperosmolar stress on the renal medulla.
It is reported that the production of superoxide is most active at acid environment.
K/Na citrate is well known as a urine alkalinization medium, and this has been evaluated earlier with standard hydration for reduction of CIN and was stated to be efficient.
We aimed to determine the efficacy of Na/K citrate in reducing the frequency of CIN in comparison to sodium bicarbonate in patients after coronary angiography.
Two hundred and ten patients with renal dysfunction [estimated glomerular filtration rate (eGFR), 60 mL/min/1.73 m2 or less] who underwent elective or emergency coronary angiography (CAG) with/without percutaneous coronary intervention (PCI) at our institution were enrolled into the study.
The patients were randomized into two groups, Group 1 - Taking Na/K citrate and Group 2 - Taking sodium bicarbonate.
Radiographic contrast agent iohexol was used.
Change in creatinine, percent change in creatinine, percent change in eGFR, change in serum potassium, and urine pH were all compared between the two groups.
There was no significant difference for prevention of CIN when comparing the Na/K citrate with sodium bicarbonate solution in patients exposed to CAG with or without PCI.
Mean absolute change in eGFR after 48 h after administration of contrast between sodium bicarbonate group and Na/K citrate group was −0.60 ± 1.58 versus −0.71 ± 1.38.
Serum potassium decreased postprocedure in the sodium bicarbonate group than in the citrate group (3.90 ± 0.33 vs.
4.14 ± 0.39).
Both agents are equally effective in reducing the incidence of CIN, but the citrate would possibly be a safer option for patients at risk of hypokalemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abu Zaid, Samih Muhammad& al-Husari, Husam E.. 2016. Na K citrate versus sodium bicarbonate in prevention of contrast-induced nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 3, pp.519-525.
https://search.emarefa.net/detail/BIM-683562
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abu Zaid, Samih Muhammad& al-Husari, Husam E.. Na K citrate versus sodium bicarbonate in prevention of contrast-induced nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 3 (May. / Jun. 2016), pp.519-525.
https://search.emarefa.net/detail/BIM-683562
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abu Zaid, Samih Muhammad& al-Husari, Husam E.. Na K citrate versus sodium bicarbonate in prevention of contrast-induced nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 3, pp.519-525.
https://search.emarefa.net/detail/BIM-683562
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 524-525
رقم السجل
BIM-683562
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر