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The effect of combined oral contraceptive pills on factor VII activity and d-dimer level in healthy and obese women
المؤلفون المشاركون
al-Saidissa, Jafar N. Jafar
Abbas, Isra S.
al-Rabii, Haytham A.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 58، العدد 1 (31 مارس/آذار 2016)، ص ص. 63-70، 8ص.
الناشر
تاريخ النشر
2016-03-31
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background : The combined pill includes a combination of an estrogen and a progestin.
Users of these pills have an increased risk of developing thrombotic disorders compared to the non-users.
Obesity is an independent risk factor for venous thromboembolism.
Obesity with oral contraceptive use increases the risk of thrombosis furthermore.
Objectives : To assess the effects of these pills in obese and healthy non-obese women on factor VII activity and D-dimer level.
Also to compare the thrombophilic effects of combined pills in women with control group of normal healthy non-users women.
Patients and Methods : This study was started on November 2014 and completed on March 2015, and included 50 females attended at Baghdad Teaching Hospital.
They were using contraceptive pills (Microgynon® ED Fe) for at least 3 months.
Females were divided into 2 equal groups; the non-obese group and the obese group.
As well 25 non-obese age-matched non-pregnant females not on contraception or taking any hormonal therapy were recruited as a control.
The hemostatic parameters done for them included the prothrombin time, activated partial thromboplastin time, factor VII, D-dimer level, and platelet count.
Results : There were significant reductions in prothrombin time in both the non-obese and obese groups compared to the control (P= 0.014 and 0.020, respectively).
The correlations between the duration of pills use and clotting times both showed insignificant differences in the study groups.
The factor VII activity in the non-obese and obese groups were significantly higher than that of the control (P= 0.041 and 0.001, respectively).
There were also significant increase in D-dimer levels in the non-obese and obese groups compared to the control (P= 0.029 and 0.038, respectively).
The platelet count was significantly increased only in the obese group compared to the control (P = 0.027).
Conclusion : The use of the combined oral contraceptive pills (Microgynon® ED Fe) is associated with significant increase in factor VII activity and the level of D-dimer that may lead to enhanced procoagulant activity.
Therefore, females should be properly assessed and monitored before starting using the pills and while on them.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abbas, Isra S.& al-Rabii, Haytham A.& al-Saidissa, Jafar N. Jafar. 2016. The effect of combined oral contraceptive pills on factor VII activity and d-dimer level in healthy and obese women. Journal of the Faculty of Medicine Baghdad،Vol. 58, no. 1, pp.63-70.
https://search.emarefa.net/detail/BIM-685323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Rabii, Haytham A.…[et al.]. The effect of combined oral contraceptive pills on factor VII activity and d-dimer level in healthy and obese women. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 1 (2016), pp.63-70.
https://search.emarefa.net/detail/BIM-685323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abbas, Isra S.& al-Rabii, Haytham A.& al-Saidissa, Jafar N. Jafar. The effect of combined oral contraceptive pills on factor VII activity and d-dimer level in healthy and obese women. Journal of the Faculty of Medicine Baghdad. 2016. Vol. 58, no. 1, pp.63-70.
https://search.emarefa.net/detail/BIM-685323
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 69-70
رقم السجل
BIM-685323
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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