Total skin electron beam therapy (TSEBT) in the management of mycosis fungoides: single institution experience
المؤلفون المشاركون
Aguib, Neveen
Rashid, Huda
Barsoum, Muhsin
Shuman, Tariq
al-Tahir, Zaynab
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 15، العدد 4 (31 ديسمبر/كانون الأول 2003)، ص ص. 275-283، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2003-12-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : to describe a protocol for total skin electron beam therapy (TSEBT) for the treatment of patients with mycosis fungicides (MF).
We report the results of treatment and prognostic factors affecting the disease-free survival (DFS).
Patients and methods: A total of 40 patients with the diagnosis of T1 / T2 mycosis fungicides have been referred to the Department of Radiation Oncology at National Cancer Institute of Cairo University from August 1997 till March 2002.
They were treated with TSEBT provided via a 6-Mev Lilac to a total absorbed dose of 35 Gy over 10 weeks.
Response rate, disease-free survival and treatment toxicity were assessed.
Results: The average age was 50 years and the median duration of skin lesions prior to any specific treatment was 4 years.
Thirty-four patients (85 %) had T1-T2 tumors.
Only 17.5 % of patients did not receive any specific treatment prior to TSEBT.
Response 4-5 weeks after end of TSEBT showed complete clinical response (CR) in 87.5 % of patients.
The median follow-up was 19.5 months, only 11 patients (27.5 %) with intial CR continued to be free of disease untill last follow-up.
The overall 2-year disease-free survival (DFS) was 66 %.
Univariate analysis showed that age, performance status and T-stage were statistically significant prognostic factors affecting DFS.
Multivariate analysis revealed that T-stage was the only independent significant factor affecting DFS.
Conclusion : for patients with MF confined to the skin, TSEBT is a safe treatment modality and is associated with high complete response (CR) rate and long DFS compared to other known modalities.
The best results can be obtained in newly diagnosed patients without previous specific treatment and T1 disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shuman, Tariq& Aguib, Neveen& al-Tahir, Zaynab& Rashid, Huda& Barsoum, Muhsin. 2003. Total skin electron beam therapy (TSEBT) in the management of mycosis fungoides: single institution experience. Journal of the Egyptian National Cancer Institute،Vol. 15, no. 4, pp.275-283.
https://search.emarefa.net/detail/BIM-68535
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shuman, Tariq…[et al.]. Total skin electron beam therapy (TSEBT) in the management of mycosis fungoides: single institution experience. Journal of the Egyptian National Cancer Institute Vol. 15, no. 4 (Dec. 2003), pp.275-283.
https://search.emarefa.net/detail/BIM-68535
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shuman, Tariq& Aguib, Neveen& al-Tahir, Zaynab& Rashid, Huda& Barsoum, Muhsin. Total skin electron beam therapy (TSEBT) in the management of mycosis fungoides: single institution experience. Journal of the Egyptian National Cancer Institute. 2003. Vol. 15, no. 4, pp.275-283.
https://search.emarefa.net/detail/BIM-68535
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 282-283
رقم السجل
BIM-68535
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر