Systemic administration of γ-hydroxybutyric acid in adolescent rat impairs contextual fear conditioning, but not cued conditioning
المصدر
Journal of Drug and Alcohol Research
الناشر
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص الإنجليزي
γ-hydroxybutyric acid (GHB) causes retrograde amnesia in juveniles and young adults.
Earlier, we have reported that in adolescent rat, GHB impairs the hidden platform task performance in the Morris water maze.
In the present study, a classical fear conditioning paradigm was used to examine the effects of GHB on the acquisition of contextual conditioning, a hippocampus-dependent associative task, and cued tone conditioning, a hippocampus-independent task, in adolescent rats.
Administration of GHB before the presentation of tone-shock pairings dose-dependently disrupted the acquisition of contextual conditioning with no effect on tone conditioning, when conditioned fear was measured 24 h later.
Administering GHB prior to testing did not disrupt either contextual or tone conditioning.
These results demonstrate that in the adolescent rat exposure to GHB preferentially disrupt hippocampal-dependent learning.
نوع البيانات
أوراق مؤتمرات
رقم السجل
BIM-685870
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sircar, Ratna& Ishiwari, Keita. 2014-12-31. Systemic administration of γ-hydroxybutyric acid in adolescent rat impairs contextual fear conditioning, but not cued conditioning. International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico). . Vol. 3 (2014), pp.1-8.Cairo Egypt : Ashdin Publishing Corporation.
https://search.emarefa.net/detail/BIM-685870
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sircar, Ratna& Ishiwari, Keita. Systemic administration of γ-hydroxybutyric acid in adolescent rat impairs contextual fear conditioning, but not cued conditioning. . Cairo Egypt : Ashdin Publishing Corporation. 2014-12-31.
https://search.emarefa.net/detail/BIM-685870
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sircar, Ratna& Ishiwari, Keita. Systemic administration of γ-hydroxybutyric acid in adolescent rat impairs contextual fear conditioning, but not cued conditioning. . International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico).
https://search.emarefa.net/detail/BIM-685870
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر