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Review of toluene actions : clinical evidence, animal studies, and molecular targets
المؤلفون المشاركون
Woodward, John J.
Rivera Garc´ıa, Mar´ıa Teresa
Cruz, Silvia L.
المصدر
Journal of Drug and Alcohol Research
العدد
المجلد 3، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
It has long been known that individuals will engage in voluntary inhalation of volatile solvents for their rewarding effects.
However, research into the neurobiology of these agents has lagged behind that of more commonly misused drugs such as psychostimulants, alcohol, and nicotine.
This imbalance has begun to shift in recent years as the serious effects of misused inhalants, especially among children and adolescents, on brain function and behavior have become appreciated and scientifically documented.
In this review, we discuss the physicochemical and pharmacological properties of toluene, a representative member of a large class of organic solvents commonly used as inhalants.
This is followed by a brief summary of the clinical and preclinical evidence showing that toluene and related solvents produce significant effects on brain structures and processes involved in the rewarding aspects of drugs.
This is highlighted by tables summarizing toluene’s effect on behaviors (e.g., reward, motor effects, learning, etc.) and cellular proteins (e.g., voltage and ligand-gated ion channels) closely associated with the actions of misused substances.
This review not only demonstrates the significant progress that has been made in understanding the neurobiological basis for solvent misuse but also reveals the challenges that remain in developing a coherent understanding of this often overlooked class of drugs of abuse.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cruz, Silvia L.& Rivera Garc´ıa, Mar´ıa Teresa& Woodward, John J.. 2014. Review of toluene actions : clinical evidence, animal studies, and molecular targets. Journal of Drug and Alcohol Research،Vol. 3, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-685897
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cruz, Silvia L.…[et al.]. Review of toluene actions : clinical evidence, animal studies, and molecular targets. Journal of Drug and Alcohol Research Vol. 3 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-685897
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cruz, Silvia L.& Rivera Garc´ıa, Mar´ıa Teresa& Woodward, John J.. Review of toluene actions : clinical evidence, animal studies, and molecular targets. Journal of Drug and Alcohol Research. 2014. Vol. 3, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-685897
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-8
رقم السجل
BIM-685897
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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