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Cocaine regulates the salt-inducible kinase (SIK1) by inducing protein phosphatase-2A expression in rat brain
المؤلفون المشاركون
Sontag, Jean Marie
Sontag, Estelle
Tesone Coelho, Carolina
Takemori, Hiroshi
Zwiller, Jean
Dietrich, Jean Bernard
المصدر
Journal of Drug and Alcohol Research
الناشر
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص الإنجليزي
We have recently documented that cocaine-induced MEF2C expression in rat brain is mediated by the activation of the saltinducible kinase SIK1, which is itself regulated by phosphorylation mechanisms.We report here that acute or chronic treatment of rats with cocaine increased the expression of the catalytic subunit of protein phosphatase PP2A in the prefrontal cortex and striatum.
Cocaine treatment also reduced the number of cortical neurons expressing SIK1 phosphorylated on Ser-577, but not on Thr-182.
To further support the hypothesis that phospho-SIK1-S577 is a substrate of PP2A, we used Neuro-2A cell cultures overexpressing either the wildtype PP2A, in which the amount of phospho-SIK1-S577 was found to be decreased, or a mutant PP2A devoid of enzymatic activity, in which the level of phospho-SIK1-S577 was increased when compared to control cells.
The data indicate that, by inducing PP2AC, cocaine regulates the nuclear location and activity of SIK1 and HDAC5, which ultimately govern the activity of CREB and MEF2C transcription factors.
The results highlight PP2A as a novel target for regulating long-term effects of cocaine
نوع البيانات
أوراق مؤتمرات
رقم السجل
BIM-686115
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sontag, Jean Marie& Sontag, Estelle& Tesone Coelho, Carolina& Takemori, Hiroshi& Zwiller, Jean& Dietrich, Jean Bernard. 2014-12-31. Cocaine regulates the salt-inducible kinase (SIK1) by inducing protein phosphatase-2A expression in rat brain. International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico). . Vol. 3 (2014), pp.1-7.Cairo Egypt : Ashdin Publishing Corporation.
https://search.emarefa.net/detail/BIM-686115
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sontag, Jean Marie…[et al.]. Cocaine regulates the salt-inducible kinase (SIK1) by inducing protein phosphatase-2A expression in rat brain. . Cairo Egypt : Ashdin Publishing Corporation. 2014-12-31.
https://search.emarefa.net/detail/BIM-686115
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sontag, Jean Marie& Sontag, Estelle& Tesone Coelho, Carolina& Takemori, Hiroshi& Zwiller, Jean& Dietrich, Jean Bernard. Cocaine regulates the salt-inducible kinase (SIK1) by inducing protein phosphatase-2A expression in rat brain. . International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico).
https://search.emarefa.net/detail/BIM-686115
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