Assessment of adenosine deaminase and total antioxidant of rheumatoid arthritis patients in Hilla City

الملخص EN

Rheumatoid arthritis is an inflammatory, autoimmune disease that causes pain, joint stiffness and loss of function.

It can occur at any age but is more common in persons over the age of 30 years and affects women more often than men The Aims of the study is Compare changes in Adenosine deaminase activity among patients with rheumatoid arthritis and control group , Compare total anti-oxidant for patients with RA and control group The study was conducted in rheumatology unit in Marjan teaching hospital in Hilla city / Babil / Iraq from 1st December 2014 to 1st February 2015.

The present study was conducted on (60) patients with rheumatoid arthritis and (53) apparently healthy subjects were taken as control group and the ages between (30–79) years.

The sera obtained from the blood of patients and healthy subjects were used to measure the concentrations of Adenosine deaminase and Total antioxidant capacity ADA is an important enzyme of purine metabolism catalyzing the irreversible deamination of adenosine to form inosine and is considered as a marker of cell mediated immunity.

RA patients have lower levels of serum antioxidants comparison to healthy person.

In comparison with the control group, the patients with RA showed a significant increase in of Adenosine deaminase (P ≤ 0.05) concentrations (120.91 ng / ml ± 7.171 vs.

50.717 ng/mL ± 5.613), and a significant decrease in Total antioxidant capacity (P ≤ 0.05) concentration(2.8214 ± 1.118 vs.

9.413 ± 1.48).