Inhibition of protein kinase mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats
المؤلفون المشاركون
Velez Hernandez, Maria E.
Vazquez Torres, Rafael
Velasquez Martinez, Maria C.
Jimenez, Lincoln
Baez, Frankie
Sacktor, Todd C.
Jimenez-Rivera, Carlos A.
المصدر
Journal of Drug and Alcohol Research
العدد
المجلد 2، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
تاريخ النشر
2013-12-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Chronic cocaine use produces long-lasting changes in reward circuits that may underlie the transition from casual to compulsive patterns of drug use.
Although strong neuroadaptations within the mesocorticolimbic system are known to occur, the specific role of these drug-induced plasticities on sensitization remains to be elucidated.
Here we investigate whether PKMζ, a protein involved in maintaining long-term potentiation (LTP), plays a role in these cocaine-induced changes in synaptic strengthening.
We performed whole-cell voltage clamp recordings of putative ventral tegmental area (VTA) dopamine (DA) cells 24 hours after 5 days of 15mg/kg i.p.
cocaine or isovolumetric saline injections.
We observed that superfusion of 5 μMZIP (PKMζ inhibitory peptide) decreased AMPA currents and AMPA/NMDA ratios only in cocaine sensitized rats.
In vivo ZIP microinfusions (10 nmol) into the VTA after cocaine sensitization decreased locomotor activity on a subsequent cocaine challenge only if ZIP is given before the withdrawal period.
On the other hand, ZIP microinfusions into the nucleus accumbens (NAc) core after a 7-day withdrawal period disrupt the expression of locomotor sensitization.
The present data provide a potentially relevant region, and timespecific PKMζ-dependent brain mechanism that enables sensitization.
Our results support the vision that addiction involves a pathological learning process.
They imply that if this synaptic strengthening is reversed, changes in the behavioral response may also be overturned.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Velez Hernandez, Maria E.& Vazquez Torres, Rafael& Velasquez Martinez, Maria C.& Jimenez, Lincoln& Baez, Frankie& Sacktor, Todd C.…[et al.]. 2013. Inhibition of protein kinase mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats. Journal of Drug and Alcohol Research،Vol. 2, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-687314
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vazquez Torres, Rafael…[et al.]. Inhibition of protein kinase mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats. Journal of Drug and Alcohol Research Vol. 2 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-687314
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Velez Hernandez, Maria E.& Vazquez Torres, Rafael& Velasquez Martinez, Maria C.& Jimenez, Lincoln& Baez, Frankie& Sacktor, Todd C.…[et al.]. Inhibition of protein kinase mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats. Journal of Drug and Alcohol Research. 2013. Vol. 2, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-687314
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 10-12
رقم السجل
BIM-687314
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر