Dopamine D1 and D3 receptors are differentially involved in cocaine-induced reward learning and cell signaling
المؤلفون المشاركون
المصدر
Journal of Drug and Alcohol Research
العدد
المجلد 1، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Memories of learned associations between the rewarding properties of drugs and environmental cues contribute significantly to craving and relapse in humans.
We have investigated how dopamine (DA) D1 and D3 receptors modulate the acquisition and extinction of cocaine-induced reward learning and associated changes in cellular signaling in reward circuits in the brain.
We found that D1 receptor mutant mice failed to acquire conditioned place preference (CPP) compared to wild-type mice over a range of cocaine doses.
By contrast, D3 receptor mutant mice exhibited potentiated acquisition of CPP compared to wild-type mice at low but not high doses of cocaine.
Activation of the extracellular signal-regulated kinase (ERK), but not the c-Jun N-terminal kinase and p38 in the nucleus accumbens, amygdala, and prefrontal cortex was attenuated in D1 receptor mutant mice and potentiated in D3 receptor mutant mice compared to wild-type mice following CPP acquisition.
D3 receptor mutant mice also exhibited delayed CPP extinction and sustained ERK activation compared to wild-type mice following extinction training.
Our results suggest that D1 and D3 receptors differentially contribute cocaine-induced reward learning by regulating, at least in part, ERK activation in reward circuits in the brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kong, Han& Xu, Ming. 2012. Dopamine D1 and D3 receptors are differentially involved in cocaine-induced reward learning and cell signaling. Journal of Drug and Alcohol Research،Vol. 1, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-687361
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kong, Han& Xu, Ming. Dopamine D1 and D3 receptors are differentially involved in cocaine-induced reward learning and cell signaling. Journal of Drug and Alcohol Research Vol. 1 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-687361
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kong, Han& Xu, Ming. Dopamine D1 and D3 receptors are differentially involved in cocaine-induced reward learning and cell signaling. Journal of Drug and Alcohol Research. 2012. Vol. 1, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-687361
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4-6
رقم السجل
BIM-687361
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر