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Effect of TongXie-YaoFang on Cl-and HCO3-transport in diarrhea-predominant irritable bowel syndrome rats
المؤلفون المشاركون
Zhao, Luqing
Wang, Zhengfang
Zhang, Shengsheng
Wu, Zhenyu
Xie, Jing
Yin, Jieyun
Lu, Xiaofang
Yang, Cheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
TongXie-YaoFang (TXYF) can effectively alleviate the symptoms of diarrhea-predominant irritable bowel syndrome (D-IBS) patients.
However, the curative mechanism has not been fully clarified.
The study was designed to investigate the effect of TXYF on the colonic ion transport induced by serotonin (5-HT) in D-IBS rats.
A method of multiple stress (neonatal maternal separation (NMS) combined with restraint stress (RS)) was used to induce the D-IBS model.
The model rats were randomly divided into two groups: NMS + RS group and TXYF-formula group, and the normal control (no handling) rats were classified as NH group.
In the NMS + RS group, the change of short-circuit current (ΔIsc) induced by 5-HT was lower than that in the NH and TXYF-formula groups.
After removing of the extracellular Cl− or HCO3- or basolateral Na+ or blocking the cystic fibrosis transmembrane conductance regulator (CFTR), Na+-K+-2Cl− cotransporter (NKCC), Na+-HCO3- cotransporter, Cl-/HCO3- exchanger, K+ channel, or Na+/K+-ATPase, respectively, there was no difference in 5-HT-induced ΔIsc among the three groups.
These data suggest that TXYF can regulate 5-HT-induced Cl− and HCO3- secretion, possibly mediated by the combined action of CFTR, NKCC, Na+-HCO3- cotransporter, Cl-/HCO3- exchanger, K+ channel, and Na+/K+-ATPase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Xiaofang& Zhang, Shengsheng& Yang, Cheng& Wang, Zhengfang& Zhao, Luqing& Wu, Zhenyu…[et al.]. 2016. Effect of TongXie-YaoFang on Cl-and HCO3-transport in diarrhea-predominant irritable bowel syndrome rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-687694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Xiaofang…[et al.]. Effect of TongXie-YaoFang on Cl-and HCO3-transport in diarrhea-predominant irritable bowel syndrome rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-687694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Xiaofang& Zhang, Shengsheng& Yang, Cheng& Wang, Zhengfang& Zhao, Luqing& Wu, Zhenyu…[et al.]. Effect of TongXie-YaoFang on Cl-and HCO3-transport in diarrhea-predominant irritable bowel syndrome rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-687694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-687694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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