Effects of sohamhyoong-tang on ovalbumin-induced allergic reaction in balb c mice
المؤلفون المشاركون
Kang, Dae Gill
Lee, Yun Jung
Jo, So Hyun
Park, Min Cheol
Kim, Dae Ki
Clement, Yuri
Lee, Ho Sub
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
IgE-mediated mast cell degranulation and excessive Th2 cells activation are major features of various allergic diseases.
Sohamhyoong-tang has been reported to have anti-inflammatory and antibacterial effects.
In this study, we investigated the inhibitory effect of Sohamhyoong-tang extract (SHHTE) on allergic symptoms and inflammatory responses in ovalbumin- (OVA-) sensitized BALB/c mice.
The mice were sensitized with OVA and alum at 2-week intervals and then orally given SHHTE for 13 days followed by intradermal OVA injection.
Administration of SHHTE significantly reduced edema formation and inflammatory-cell infiltration in ear tissues.
Total and OVA-specific IgEs as well as proinflammatory cytokine TNF-α and Th2-associated cytokine IL-4 levels were lower in the SHHTE-treated group than in the vehicle.
SHHTE treatment significantly suppressed both mRNA and protein levels of IL-4 and IL-5 in OVA-stimulated splenocytes.
SHHTE decreased Th1 (IFN-γ) and Th17 (IL-17a) cytokine mRNA expression but increased Treg cytokines (IL-10 and TGF-β1).
Moreover, SHHTE significantly inhibited degranulation of RBL-2H3 cell line in a dose-dependent manner.
Thus, SHHTE efficiently inhibited the allergic symptoms in an OVA-sensitized mouse model and its action may correlate with the suppression of IgE production by increasing IL-10 and TGF-β1, which can limit the function of other T helper cells and prevent the release of inflammatory mediators from mast cells.
These results suggest that SHHTE could be a therapeutic agent for treating various allergic diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jo, So Hyun& Lee, Yun Jung& Kang, Dae Gill& Lee, Ho Sub& Kim, Dae Ki& Park, Min Cheol…[et al.]. 2016. Effects of sohamhyoong-tang on ovalbumin-induced allergic reaction in balb c mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-687696
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jo, So Hyun…[et al.]. Effects of sohamhyoong-tang on ovalbumin-induced allergic reaction in balb c mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-687696
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jo, So Hyun& Lee, Yun Jung& Kang, Dae Gill& Lee, Ho Sub& Kim, Dae Ki& Park, Min Cheol…[et al.]. Effects of sohamhyoong-tang on ovalbumin-induced allergic reaction in balb c mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-687696
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-687696
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر