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Physiological significance of exhaled carbon monoxide in asthmatics
المؤلف
المصدر
Journal of the Medical Research Institute
العدد
المجلد 28، العدد 1 (31 مارس/آذار 2007)، ص ص. 64-69، 6ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2007-03-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : There were evidences that CO has the potential to contribute to the pathophysiology of asthma in pre-clinical asthma models.
Aim : This study was undertaken to investigate the relationship between exhaled CO concentrations and some pathophysiological components of asthma including airway obstruction, airway hyperresponsiveness and TGF-1, as an inflammatory marker, in asthmatic subjects.
Subjects and Methods : Ten normal subjects (5 female and 5 males) and fifteen asthmatic patients (7 females and 8 males) were included in this study.
Pulmonary function tests, exhaled CO monitoring, Methacholine inhalation challenge (MIC) and TGF-1measurements in induced sputum by ELISA were performed in all subjects.
Results : Asthmatics exhibited lower mean values of FEV1 (p < 0.001), FEV1 / FVC % (p < 0.01), FEF25-75 (p < 0.001), and higher mean exhaled CO concentration (p < 0.001), and sputum TGF-1 (p < 0.001) than controls.
Also, in MIC, asthmatics demonstrated airway hyperresponsiveness (PD20- FEV1 was 0.0711 ± 0.04 mg / ml) whereas controls showed no bronchoconstriction with provocation test.
Elevated exhaled CO values were significantly correlated with FEV1 (r = 0.838, p < 0.001), FEF25-75 % (r = 0.829, p < 0.001), FEV1 / FVC % (r = 0.903, p < 0.001), PD20-FEV1 (r = 0.855, p < 0.001) and TGF-1 (r = 0.939, p < 0.001).
Conclusion : The increased exhaled CO production is not only an indicator of inflammatory activity but also could be a causative link in the pathophysiology of asthma.
So, further elucidation of the potential role of CO may offer a therapeutic target for bronchial asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Ghazzali, Muhammad. 2007. Physiological significance of exhaled carbon monoxide in asthmatics. Journal of the Medical Research Institute،Vol. 28, no. 1, pp.64-69.
https://search.emarefa.net/detail/BIM-69108
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Ghazzali, Muhammad. Physiological significance of exhaled carbon monoxide in asthmatics. Journal of the Medical Research Institute Vol. 28, no. 1 (2007), pp.64-69.
https://search.emarefa.net/detail/BIM-69108
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Ghazzali, Muhammad. Physiological significance of exhaled carbon monoxide in asthmatics. Journal of the Medical Research Institute. 2007. Vol. 28, no. 1, pp.64-69.
https://search.emarefa.net/detail/BIM-69108
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Include bibliographical references : p. 68-69ographical references, p.68-69
رقم السجل
BIM-69108
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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