Comparative study of immunohistochemical expression of moesin, cytokeratin 14 and MMP7 in oral squamous cell carcinoma and oral verrucous carcinoma
المؤلفون المشاركون
Jubair, Karawan Khalil
Yunus, Wasan Hamdi
Abd Allah, Bashshar Hamid
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 28، العدد 2 (30 يونيو/حزيران 2016)، ص ص. 52-57، 6ص.
الناشر
تاريخ النشر
2016-06-30
دولة النشر
العراق
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity that exhibits certain histological variations.
Verrucous carcinoma (VC) is an uncommon exophytic low-grade welldifferentiated variant of SCC.
Cellular differentiation and morphology play important roles in cell functions and maintenance of structural integrity .As the cancer is a malignant process in which disorder of the cell growth and behavior occurs, such changes may differ in different tumor types and within different grades of the same tumor.
Materials and Methods:Forty two formalin–fixed, paraffin–embedded tissue blocks were included in this study (30 blocks were diagnosed as OSCC and 12 blocks were diagnosed as OVC).
An immunohistochemical staining was performed using anti moesin, anti CK14 and anti MMP7 monoclonal antibodies.
Results: Moesinimmunoreactivity was recognized in all the studied groups with predominant cytoplasmic expression in OSCC & membranous expression in OVC.
No difference was noticed between 2 studied groups &between different grades of OSCC.
Cytokeratin 14 positivity was noticed in all studied groups with significant difference between OSCC&OVC (p = 0.012) & there was a significant difference between the different grade of OSCC (p = 0.047).
MMP7 expression was observed in the all studied groups with predominant cytoplasmic pattern in OSCC & nuclear pattern in OVC.
No difference was found between the 2studied groups &between the different grades of SCC.
A Strong positive linear correlation between MMP7&CK14 was noticed.
Conclusion : Verrucous carcinoma has a specific pattern for moesin and MMP7 that differs from OSCC, however; the difference is not significant.
CK14 immunoreactivity indicated a significant difference in the degree of cellular differentiation between OSCC &OVC
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jubair, Karawan Khalil& Yunus, Wasan Hamdi& Abd Allah, Bashshar Hamid. 2016. Comparative study of immunohistochemical expression of moesin, cytokeratin 14 and MMP7 in oral squamous cell carcinoma and oral verrucous carcinoma. Journal of Baghdad College of Dentistry،Vol. 28, no. 2, pp.52-57.
https://search.emarefa.net/detail/BIM-691832
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jubair, Karawan Khalil…[et al.]. Comparative study of immunohistochemical expression of moesin, cytokeratin 14 and MMP7 in oral squamous cell carcinoma and oral verrucous carcinoma. Journal of Baghdad College of Dentistry Vol. 28, no. 2 (Jun. 2016), pp.52-57.
https://search.emarefa.net/detail/BIM-691832
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jubair, Karawan Khalil& Yunus, Wasan Hamdi& Abd Allah, Bashshar Hamid. Comparative study of immunohistochemical expression of moesin, cytokeratin 14 and MMP7 in oral squamous cell carcinoma and oral verrucous carcinoma. Journal of Baghdad College of Dentistry. 2016. Vol. 28, no. 2, pp.52-57.
https://search.emarefa.net/detail/BIM-691832
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 57
رقم السجل
BIM-691832
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر