Diagnostic utility of biomarkers in diagnosis of early stages of neonatal sepsis in neonatal intensive care unit in Egypt
المؤلفون المشاركون
al-Sunbati, Marwa M.
al-Sharany, Wala
Abd al-Hamid, Tamir A.
Yunus, Iman R.
Muhammad, Nadiyah A.
Abd al-Raziq, Abd al-Rahman Ahmad
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 64، العدد 2 (30 يونيو/حزيران 2016)، ص ص. 91-96، 6ص.
الناشر
تاريخ النشر
2016-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Neonatal sepsis is considered one of the major causes of morbidity and mortality in NICUs.
To avoid unnecessary treatment of non-infected neonates, emergence of multidrug resistance organisms, prolonged hospitalization and a considerable economic burden, particularly in developing countries with poorly-equipped NICUs, an early, sensitive and specific laboratory test would be helpful to guide clinicians in neonatal units to decide whether or not to start antibiotics.
Objective: C-reactive protein (CRP), tumor necrosis factor-a (TNF), interleukin-6 (IL-6) and interleukin-1 (IL-1) were measured in an attempt to identify a set of tests which can confirm or refute the diagnosis of neonatal sepsis at an early stage before administration of antibiotics.
Methods: Assessment of serum levels of CRP, TNF-a, IL-6 and IL-1 was done using quantitative enzyme immunoassay sandwich technique in 116 neonates (36 newborns with clinically suspected sepsis, 48 newborns with culture-proven sepsis and 32 infection-free neonates).
Results: The cutoff levels for CRP at >12 mg/l had a sensitivity of 91% and specificity of 100%, for TNF-a at >113.2 ng/ml had a sensitivity of 83% and specificity of 100%, for IL-6 at >16.8 pg/ml had a sensitivity of 100% and specificity of 47%, and for IL-1 at >15 pg/ml had a sensitivity of 100% and specificity of 47% for the diagnosis of infection before antibiotics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sunbati, Marwa M.& al-Sharany, Wala& Yunus, Iman R.& Muhammad, Nadiyah A.& Abd al-Hamid, Tamir A.& Abd al-Raziq, Abd al-Rahman Ahmad. 2016. Diagnostic utility of biomarkers in diagnosis of early stages of neonatal sepsis in neonatal intensive care unit in Egypt. Egyptian Pediatric Association Gazette،Vol. 64, no. 2, pp.91-96.
https://search.emarefa.net/detail/BIM-691956
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sunbati, Marwa M.…[et al.]. Diagnostic utility of biomarkers in diagnosis of early stages of neonatal sepsis in neonatal intensive care unit in Egypt. Egyptian Pediatric Association Gazette Vol. 64, no. 2 (Jun. 2016), pp.91-96.
https://search.emarefa.net/detail/BIM-691956
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sunbati, Marwa M.& al-Sharany, Wala& Yunus, Iman R.& Muhammad, Nadiyah A.& Abd al-Hamid, Tamir A.& Abd al-Raziq, Abd al-Rahman Ahmad. Diagnostic utility of biomarkers in diagnosis of early stages of neonatal sepsis in neonatal intensive care unit in Egypt. Egyptian Pediatric Association Gazette. 2016. Vol. 64, no. 2, pp.91-96.
https://search.emarefa.net/detail/BIM-691956
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 95-96
رقم السجل
BIM-691956
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر