Evaluation of solitary thyriod cold nodules wioth technetium-99m ses-amibi and thalium -201
المؤلفون المشاركون
Fawzi, Ashraf
Wajih, Shirin
Sabir, Rafat Ali
Sedik, Azzah
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 13، العدد 2 (30 يونيو/حزيران 2001)، ص ص. 147-155، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2001-06-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
This is a prospective study, including 54 patients with solitary cold thyroid nodules detected on the standard technetium-99m pertechnetate scintigraphy in the period between September 1999 and February 2001.
All patients underwent thyroid ultrasonography, triple-phase thyroid scan with Technetium-99m pertechnetate (99mTc), Tech-netium-99m sestamibi (99mTc-MIBI) and thallium-201 (201TI) followed by fine needle aspiration cytology (FNAC).
All patients, except those with thyroiditis, were subjected to surgery for histopathologically diagnosis.
Quantitative analysis was performed by drawing a region of interest (ROI) over the nodule and contralateral normal thyroid tissue.
The lesion to normal thyroid (L / N) uptake ratio on early (ER) and late image (LR) were calculated.
Based on histopathologically examination, there were 19 patients (35 %) with well differentiated carcinoma and 35 patients (65 %) with benign lesions.
The mean uptake L / N ratios for benign and malignant thyroid nodules were 1.25 ± 0.47 and 1.56 ± 0.24 in the early 99mTc-MIBI scan ; 0.99 ± 0.18 and 2.38 ± 0.71 in the late 99mTc-MIBI scan.
There was no statistical difference between the mean early L / N uptake ratio of benign versus malignant thyroid lesions using 99mTc-MIBI (p = 0.073).
On the other hand, there was a statistically significant difference between the mean late L / N uptake ratios of benign versus malignant thyroid nodules using 99mTc-MIBI (p = 0.001).
Also, there was no significant difference in the mean early L/N uptake ratios for thallium-201 scan between benign (1.29 ± 0.41) and malignant nodules (1.35 ± 0.17) (p = 0.133).
A significant difference in the late thallium scan between the mean uptake ratio in benign (1.06 ± 0.12) and malignant nodules (1.74 ± 0.31) was noted (p = 0.01).
To determine the threshold levels to differentiate between benign and malignant nodules, a receiver operating characteristic (ROC) analysis was applied.
The mean uptake ratios of 1.31 and 1.48 for early and late 99mTc-MIBI scans and 1.23 and 1.34 for early and late 201TI scans were selected, respectively.
Based on these threshold values, the sensitivity and specificity of early 99mTc-MIBI scan were 84.2 % and 83.3%, whereas they were 89.5 % and 90 % for late 99mTc-MIBI.
A lower sensitivity and specificity for early thallium-201 scan of 78.9 %, and 66.7 % and 84.2 % and 86.7 % for late thallium-201 were found.
In conclusion, LR for 99mTc-MIBI and 201TI studies was superior to ER in differentiating malignant thyroid nodules.
Also, LR of 99mTc-MIBI was more sensitive than that of 201TI scan in diagnosis of benign versus malignant thyroid nodules.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sabir, Rafat Ali& Wajih, Shirin& Sedik, Azzah& Fawzi, Ashraf. 2001. Evaluation of solitary thyriod cold nodules wioth technetium-99m ses-amibi and thalium -201. Journal of the Egyptian National Cancer Institute،Vol. 13, no. 2, pp.147-155.
https://search.emarefa.net/detail/BIM-69220
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sabir, Rafat Ali…[et al.]. Evaluation of solitary thyriod cold nodules wioth technetium-99m ses-amibi and thalium -201. Journal of the Egyptian National Cancer Institute Vol. 13, no. 2 (Jun. 2001), pp.147-155.
https://search.emarefa.net/detail/BIM-69220
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sabir, Rafat Ali& Wajih, Shirin& Sedik, Azzah& Fawzi, Ashraf. Evaluation of solitary thyriod cold nodules wioth technetium-99m ses-amibi and thalium -201. Journal of the Egyptian National Cancer Institute. 2001. Vol. 13, no. 2, pp.147-155.
https://search.emarefa.net/detail/BIM-69220
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 154-155
رقم السجل
BIM-69220
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر