![](/images/graphics-bg.png)
Evaluation of retinoblastoma Gene product (rb) as a prognostic indicator in bladder carcinoma
المؤلفون المشاركون
al-Hifnawi, Nadiyah Jalal
Shuayb, M.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 13، العدد 3 (30 سبتمبر/أيلول 2001)، ص ص. 185-190، 6ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2001-09-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : despite precise pathologic staging and grading, we are unable to predict clinical outcome in patients with bladder cancer.
The retinoblastoma susceptibility gene (RB) a prototype of tumour suppressor genes, thought to function as a cell cycle regulator, has recently been associated with development and / or progression of bladder cancer, as well as sarcoma and small cell lung cancer.
Purpose : the aim of this study was to investigate the hypothesis that altered patterns of RB expression correlate with prognosis and with tumour cell growth fraction in bladder cancer.
Methods : Tumours from 40 patients with primary transitional cell carcinoma were studied.
Expression of RB gene product was assessed immunohistochemically.
The proportion of cells expressing the ki67 antigen was also detected.
Results : three patterns of RB protein staining were observed, absent n = 12, heterogenous n = 23 and strongly homogenous n = 5.
Cases with loss of RB protein and those with apparent over expression were considered to have an altered RB protein expression.
Altered expression of RB was significantly associated with muscle invasive growth and high tumour grade (p < 0.0001, p < 001) respectively.
The 5 years survival rate was significantly decreased in patients with altered RB protein expression compared with patients with normal expression of RB (p < 0.05).
There were significant differences in the ki67 index between poorly (G3) and better (G1/G2) differentiated tumours and between invasive and non-muscle invasive tu- mours Conclusion : this study suggests that altered patterns of RB protein expression may be an important prognostic variable in patients presenting with invasive bladder can-car.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hifnawi, Nadiyah Jalal& Shuayb, M.. 2001. Evaluation of retinoblastoma Gene product (rb) as a prognostic indicator in bladder carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 13, no. 3, pp.185-190.
https://search.emarefa.net/detail/BIM-69297
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hifnawi, Nadiyah Jalal& Shuayb, M.. Evaluation of retinoblastoma Gene product (rb) as a prognostic indicator in bladder carcinoma. Journal of the Egyptian National Cancer Institute Vol. 13, no. 3 (Sep. 2001), pp.185-190.
https://search.emarefa.net/detail/BIM-69297
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hifnawi, Nadiyah Jalal& Shuayb, M.. Evaluation of retinoblastoma Gene product (rb) as a prognostic indicator in bladder carcinoma. Journal of the Egyptian National Cancer Institute. 2001. Vol. 13, no. 3, pp.185-190.
https://search.emarefa.net/detail/BIM-69297
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 190
رقم السجل
BIM-69297
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)