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Effect of curcumin on cadmium-induced oxidative testicular damage in rats
المؤلفون المشاركون
Salamah, Afrah F.
al-Bahr, S. M.
المصدر
Journal of the Medical Research Institute
العدد
المجلد 28، العدد 2 (30 يونيو/حزيران 2007)، ص ص. 167-173، 7ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2007-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Exposure to cadmium is associated with various pathological conditions that include reproductive dysfunction.
Generation of oxidative stress is one of the plausible mechanisms for cadmiuminduced cellular deteriorations.
Curcumin is a promising natural drug against cancer, inflammation and oxidative stress.
Aim and Methods : The present study investigates the efficacy of curcumin to attenuate cadmium-induced oxidative damage in adult rat testicles.
A total of 40 male albino rats were divided into four groups (10 rats each).
The first group served as control and received corn oil only (5 ml / kg body weight).
Rats of the second group received cadmium at the dose of 25 mg / L of drinking water.
Rats of the third group received curcumin dissolved in corn oil at a dose of 15 mg / 5 ml / kg body weight while rats of the fourth group received both cadmium and curcumin with same mentioned dose and route of administration, for two months, the duration of the experiment.
Results and Conclusion : The use of curcumin in attenuating the damaged effects of cadmium on reproduction of male rats, improved its spermatogenic damage, decreased sperm count, testosterone level and inducing antioxidant defense.
The present study demonstrated that, administration of curcumin attenuated the adverse effects of cadmium in rats by inducing antioxidant defense mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salamah, Afrah F.& al-Bahr, S. M.. 2007. Effect of curcumin on cadmium-induced oxidative testicular damage in rats. Journal of the Medical Research Institute،Vol. 28, no. 2, pp.167-173.
https://search.emarefa.net/detail/BIM-69304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salamah, Afrah F.& al-Bahr, S. M.. Effect of curcumin on cadmium-induced oxidative testicular damage in rats. Journal of the Medical Research Institute Vol. 28, no. 2 (2007), pp.167-173.
https://search.emarefa.net/detail/BIM-69304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salamah, Afrah F.& al-Bahr, S. M.. Effect of curcumin on cadmium-induced oxidative testicular damage in rats. Journal of the Medical Research Institute. 2007. Vol. 28, no. 2, pp.167-173.
https://search.emarefa.net/detail/BIM-69304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Include bibliographical references : p. 172-173
رقم السجل
BIM-69304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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